The nature and extent of mucosal alterations in 30 consecutive surgical specimens removed for urothelial neoplasia were evaluated by systematic mapping. The findings correlated with pertinent pathological, cytological and clinical data. Generally, the grade of the principal neoplasm paralleled the degree of epithelial disturbance in the grossly normal urothelium, high grade carcinomas being associated consistently with severe changes and low grade cancers with hyperplasia only. Cytological studies reflected accurately the grade of the principal neoplasm, and the presence of concomitant contiguous and remote mucosal abnormalities.
We describe a case of neuroblastoma presenting as a paratesticular mass in infancy. To our knowledge this is the first case of a paratesticular neuroblastoma reported in the literature. An operation combined with radiotherapy and chemotherapy has achieved long-term survival despite obvious multifocal disease. Seven years after treatment of the inital tumor the patient presented with a subependymal giant cell astrocytoma, an extremely rare neuroectodermal tumor. Discussion is directed to possible explanations for this unusual case of multifocal, metachronous neuroectodermal neoplasms.
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