BackgroundThe presence of different breast cancer receptor status may impact ovarian stimulation outcomes.AimTo study the association between oestrogen receptor (ER) status in breast cancer patients and fertility preservation outcomes in a major tertiary referral centre.Materials and MethodsWomen who underwent fertility preservation following the diagnosis of breast cancer from 2008 to 2018 were included in the study. Patient age, ovarian stimulation parameters and laboratory outcomes were recorded and compared between the ER positive and negative groups. The primary outcome was total number of oocytes frozen. Secondary outcomes included total number of oocytes collected, mature oocytes, and embryos frozen.ResultsThe women included in the study (n = 214) were analysed in the following groups based on their fertility preservation method: oocyte freezing (n = 131), embryo freezing (n = 70), and both embryo and oocyte freezing (n = 13). There was an increase in the mean (but not mature) number of oocytes frozen (12.4 and 9.2, P‐value = 0.03) favouring the ER positive group, even though the women in this group were older (35.0 and 33.4, P‐value of 0.03). There is no difference in the starting follicle‐stimulating hormone dose, duration of stimulation, mature oocytes collected, and embryos frozen in both groups.ConclusionPatients with ER positive breast cancer may have more positive ovarian stimulation outcomes.
We aim to analyze the data from our colposcopy clinic since its transition to the new cervical screening program to determine its effectiveness in clinical practice. Materials and Methods: We extracted data from hospital electronic records, which was analyzed by a bio-statistician. Associations and concordance between referring (Human Papilloma Virus) HPV types, Liquid Based Cytology (LBC), colposcopic impression and cervical biopsy were calculated and analyzed. Results: Data from 262 women who attended our colposcopy clinic from December 2017 to November 2018 was analyzed. Our study showed that the volume of referrals had increased by 6-fold since the implementation of the new cervical screening program in Australia. HPV Other (non 16/18) had the highest prevalence among women referred and accounted for the highest number of high-grade referrals to our unit. Conclusion: 83.3% of referrals with HPV Other (non 16/18) had abnormal cytology. HPV Other appears to be the most pathogenic of all HPV subtypes. The concordance between colposcopic impression and cervical biopsy was 61.9%.
Background: Aggressive angiomyxoma is a benign, rare, and locally aggressive neoplasm that can be found in the perineal or pelvic region of female patients of the reproductive age group. Case: We present the first case report in Australia of a vaginal aggressive angiomyxoma in an obstetric patient during her 24th week of pregnancy. Results: The patient underwent surgical excision and close follow-up with no evidence of tumor recurrence in 2 years. Conclusion: Aggressive angiomyxoma is associated with a high rate of local recurrence and the recommended approach is preoperative imaging, surgery, and close follow-up. ( J GYNECOL SURG 36:151
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