Derivatives of yeast cell wall (YCW) have been studied for their potential
prebiotic effects. Recently, new purified and soluble preparations have been
developed in an attempt to increase their biological actions. Two YCW
preparations, one conventional and another with higher solubility of the mannan
oligosaccharide fraction, were evaluated on dogs. One food formulation was used,
divided into the following treatments: CON–control, without yeast cell wall
addition; YCW–addition of 0.3% of a conventional yeas cell wall extract;
YCWs–addition of 0.3% of a yeast cell wall extract with high mannan
oligosaccharide solubility. Twenty-four beagle dogs were used, eight per food,
distributed on a block design. Blocks lasted 32 days, and TNF-a, IL-6, IL-10,
ex vivo production of hydrogen peroxide and nitric oxide by
peripheral neutrophils and monocytes, phagocytic index, and fecal IgA were
evaluated at the beginning and end of each period. Additionally, nutrient
digestibility, feces production and quality, and fermentation products were
quantified. The results were evaluated by analysis of variance and compared
using the Tukey test (P<0.05), using the basal immunological parameters as a
covariate. The inclusion of YCWs reduced fat digestibility (P<0.05),
increased the concentration of butyrate and putrescine, and reduced lactate in
feces (P<0.05), showing that mannan oligosaccharide solubilization resulted
in higher fermentation of this compound and altered the metabolism of the gut
microbiota. Lower IL-6 on serum was verified for dogs fed the YCWs diet
(P<0.05), suggesting a reduction in the inflammatory activity of dogs. Higher
phagocytic index was verified for peripheral monocytes after the intake of the
YCW food, suggesting better innate immunity. In conclusion, the solubilization
of the mannooligosaccharide fraction alters its interaction with gut microbiota
and biological actions in animals, although both yeast cell wall preparations
exhibited prebiotic effects on dogs.
The aim of this report was to describe the clinical findings and therapeutic management of a case of papillary adenocarcinoma of the descending colon in a Beagle. The patient presented soft stools, haematochezia, tenesmus, and dyschezia. Clinical examination revealed alterations on the ultrasonographic features of the descending colon suggestive of colitis and neoplasia. Following local mass resection, histopathology analysis revealed mild lymphoplasmocytic enteritis and papillary adenocarcinoma of the colon. Enterectomy for tumoral resection and biopsy of locoregional lymph nodes were carried out. Subsequent to the surgical procedure, it was possible to confirm the previous diagnosis and the tumor was classified as intestinal intraluminal papillary adenocarcinoma, with incomplete surgical margins. Adjuvant chemotherapy was performed using carboplatin, cyclophosphamide, and piroxicam, leading to remission of clinical signs and absence of any clinical or imaging alterations compatible with the patient's previous clinical condition. Palavras-chave: canino, neoplasia intestinal, oncologia
Neutering females may be associated to weight gain in dogs. In order to diagnose possible alterations, such as diabetes and hyperlipidemias, laboratory assessment of carbohydrate and lipid metabolism is important. The aim of this study was to verify glycemia and serum lipid profile in non-spayed and spayed female dogs, and associate these results with the body condition score. Thirty-two spayed (n=16) and non-spayed (n=16) female dogs had their blood collected for biochemical analysis, and were classified as to their body condition score (BCS). Nine had normal BCS, 10 were overweight, and 13 were obese. Little difference was observed among spayed and non-spayed dogs. Glycemia of spayed canine females is higher than that of non-spayed dogs, regardless of the body condition score. Likewise, total cholesterol levels are higher in non-spayed females. The HDL is higher in non-spayed obese dogs than in spayed dogs with the same body condition, this parameter did not differ in other weight groups. Contrary to what happens in post-menopausal women, spaying dogs does not seem to have such a strong effect on the metabolic parameters assessed. This study revealed unique results, where neither spaying nor weight group had a strong association with metabolic alterations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.