Background Neurocognitive deficits are present in bipolar disorder (BD) patients and their unaffected (nonbipolar) relatives, but it is not clear which domains are most often impaired and the extent of the impairment resulting from shared genetic factors. In this literature review, we address these issues and identify specific neurocognitive tasks most sensitive to cognitive deficits in patients and unaffected relatives. Method We conducted a systematic review in Web of Science, PubMed/Medline and PsycINFO databases. Results Fifty-one articles assessing cognitive functioning in BD patients (23 studies) and unaffected relatives (28 studies) were examined. Patients and, less so, relatives show impairments in attention, processing speed, verbal learning/memory, and verbal fluency. Conclusion Studies were more likely to find impairment in patients than relatives, suggesting that some neurocognitive deficits may be a result of the illness itself and/or its treatment. However, small sample sizes, differences among relatives studied (e.g., relatedness, diagnostic status, age), and differences in assessment instruments may contribute to inconsistencies in reported neurocognitive performance among relatives. Additional studies addressing these issues are needed.

Although research has focused on how inconsistencies in alibi statements are perceived by law enforcement and legal decision-makers, less attention has been paid to the cognitive factors that may mitigate such inconsistencies. Using a novel, ecologically-valid paradigm, across two experiments (507 events for N=134), we examined the accuracy, level of detail, and memory characteristics of participant-generated alibis for schema-consistent and-inconsistent events, and whether mental reinstatement of context (MRC) led to improved alibis compared to time-cueing. Participants reported their typical weekly activities, provided real-time reports of their activities during a two-week period, and reported participant-specific schema-consistent and-inconsistent events using time-cues and MRC. Our results suggest schema-consistent events are reported more accurately than inconsistent events, and that MRC does not improve alibi accuracy over timecueing. When reporting atypical events, participants provided alibis by reporting what they thought they would normally be doing during that time. Together, these findings quantify how difficult remembering an alibi can be, reinforce that people often rely on schemas, and that mnemonic strategies to increase alibi accuracy are likely to fail, even if they work in other domains. We discuss how the current research adds to recent work on boundary conditions for the efficacy of MRC.

BackgroundAnabaptists comprise large and growing Amish and Mennonite populations with a unique genetic heritage and cultural background. Little is known about the symptoms and course of major mood disorders in Anabaptists. Even less is known about the impact of potential moderators on symptom severity and course.MethodsA sample of Amish and Mennonite participants with bipolar, recurrent unipolar, or schizoaffective bipolar disorder (n = 155) were systematically evaluated with a well-validated instrument. Cases were compared with non-Anabaptist participants (n = 155) matched for age, sex, and psychiatric diagnosis and evaluated by the same methods.ResultsDespite substantial cultural differences, the profile of manic and depressive symptoms during illness episodes did not significantly differ between the two groups. Alcohol use disorder (AUD) was significantly less frequent among Anabaptists, and was associated with more major depressive episodes and more hospitalizations for major depression in Anabaptist, but not non-Anabaptist participants. Lifetime history of head injury showed a trend toward association with more episodes of major depression in both Anabaptist and non-Anabaptist groups that did not withstand multiple test correction.ConclusionsThe presentation of a highly heritable psychiatric illness such as bipolar disorder does not differ in cases drawn from genetically unique Anabaptist populations. However, alcohol comorbidity, head injury, and their effects on illness course suggest some differences that deserve further investigation.