The results indicate that CHR individuals display substantial emotion awareness and emotion-regulation deficits, at severity comparable with those observed in individuals with schizophrenia. Such deficits, in particular difficulties describing feelings, predate the onset of psychosis and contribute significantly to poor SF in this population.
Background
Prior studies have implicated baseline positive and negative symptoms as
predictors of psychosis onset among individuals at clinical high risk (CHR), but none
have evaluated latent trajectories of symptoms over time. This study evaluated the
dynamic evolution of symptoms leading to psychosis onset in a CHR cohort.
Method
100 CHR participants were assessed quarterly for up to 2.5 years. Latent
trajectory analysis was used to identify patterns of symptom change. Logistic and
proportional hazards models were employed to evaluate the predictive value for psychosis
onset of baseline symptoms and symptom trajectories.
Results
Transition rate to psychosis was 26%. Disorganized communication (i.e.,
subthreshold thought disorder) presented an increased hazard for psychosis onset, both
at baseline (Hazard Ratio (95% CI) = 1.4 (1.1–1.9)) and as a
trajectory of high persistent disorganized communication (Hazard Ratio (95% CI)
= 2.2 (1.0–4.9)). Interval clinical data did not improve the predictive
value of baseline symptoms for psychosis onset.
Conclusions
High baseline disorganized communication evident at ascertainment tended to
persist and lead to psychosis onset, consistent with prior behavioral and speech
analysis studies in similar cohorts. Remediation of language dysfunction therefore may
be a candidate strategy for preventive intervention.
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