Background:The ABCA4 protein is proposed to transport all-trans-retinal from the outer segment discs of retinal rod and cone photoreceptors. Results: 11-cis-Retinal bound specifically and with high affinity to the NBD1 domain of hABCA4. Conclusion: The NBD1 domain plays further roles in addition to nucleotide hydrolysis. Significance: ABCA4 may play a novel role in the visual transduction cycle involving 11-cis-retinal.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.