SUMMARYWe have previously shown in mice that antibodies can be induced to synthetic malaria peptides conjugated to myeobacterial antigens, such as purified protein derivative (PPD) or heat shock proteins (hsp), and given in the absence of adjuvants after a previous priming with bacille CalmetteGucrin (BCG), In the present study we investigated this model of itnmunizatJon in the non-human primates, Saimiri sciureus monkeys. Monkeys primed wilh BCG subcutaneously and then imtTiuni,^ed subcutaneously with the Plasmodium falcipaium sporozoitc (NANP)4ii synthetic peptide conjugated to PPD or myeobacterial hsp of 65 or 70 kD, in the absence of adjuvants, produced antipeptide and iinli-sporozoite IgG antibodies. Interestingly, thecarrierejfect ofthc h.sp of 70 kD for the induction of anti-(NANP)4(i antibodies was also observed in the absence ofa previous priming wilh BCG, These data suggest that such a vaccination strategy tnay be applied to humans.

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