Background/Aim:Ablative techniques such as radiofrequency ablation or non-thermal electrochemical treatment (ECT) are used to manage unresectable liver metastases. Although ECT is not affected by the cooling effect from adjacent vessels, there is a paucity of data available on ECT.Materials and Methods:We used porcine livers to establish an organ model with portal venous and hepatic arterial blood flow for a standardized analysis of the relationship between dose (electric charge) and response (volume of necrosis).Results:This model allowed us to study pressure-controlled perfusion of portal venous and hepatic arterial circulation in the absence of a capillary leak. A specially designed guiding template helped us place platinum electrodes at reproducible locations. With two electrodes, there was a linear relationship between charges of no more than 200 C and necrosis. The relationship was logarithmic at charges of 400-600 C. Larger electrode spacing led to a significant increase in necrosis. We measured pH values of 0.9 (range: 0.6-1.3) at the anode and 12.6 (range: 11.6-13.4) at the cathode.Conclusions:Using a perfusion model, we established an experimental design that allowed us to study ECT in the liver of large animals without experiments on living animals. An electrode template helped us improve the standardized analysis of dose-response relationships. ECT created reproducible and sharply demarcated areas of necrosis, the size of which depended on the charge delivered as well as on the number and spacing of electrodes. Doses higher than 600 C require longer treatment times but do not increase the area of necrosis (logarithmic dose-response relationship).
The control of flow separation on aerodynamic surfaces remains a fundamental goal for future air transportation. On airplane wings and control surfaces, the effects of flow separation include decreased lift, increased drag, and enhanced flow unsteadiness and noise, all of which are detrimental to flight performance, fuel consumption, and environmental emissions. Many types of actuators have been designed in the past to counter the negative effects of flow separation, from passive vortex generators to active methods like synthetic jets, plasma actuators, or sweeping jets. At the Chair of Aerodynamics at TU Berlin, significant success has been achieved through the use of pulsed jet actuators (PJA) which operate by ejecting a given amount of fluid at a specified frequency through a slit-shape slot on the test surface, thereby increasing entrainment and momentum in a separating boundary layer and thus delaying flow separation. Earlier PJAs were implemented using fast-switching solenoid valves to regulate the jet amplitude and frequency. In recent years, the mechanical valves have been replaced by fluidic oscillators (FO) in an attempt to generate the desired control authority without any moving parts, thus paving the way for future industrial applications.
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