Highlights d Neonatal skin is enriched with immature fat and adipogenic dermal fibroblasts d Dermal immature fat and adipogenic-antimicrobial dFBs are lost with age d TGF-b pathway promotes the age-related adipogenic-tofibrotic switch of dFBs d Inhibition of TGFBR restores antimicrobial function of dFBs in adult mice
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