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The next decade is likely to produce any number of global challenges that will affect health and health care, including pan-national infections such as the new coronavirus COVID-19 and others that will be related to global warming. Nurses will be required to react to these events, even though they will also be affected as ordinary citizens. The future resilience of healthcare services will depend on having sufficient numbers of nurses who are adequately resourced to face the coming challenges.

These positive examples in recent years must not mask the dangerous consequences of failing to meet the Paris Agreement, the past two decades of relative inaction, the economies and sectors currently lagging behind, and the enormity of the task ahead, which leave achieving the Agreement's aims in a precarious position. Indeed, much of the data presented should serve as a wake-up call to national governments, businesses, civil society, and the health profession. However, as this report demonstrates, the world has already begun to embark on a path to a lowcarbon and healthier world. Whilst the pace of action must greatly accelerate, the direction of travel is set.

Decreasing labour productivity, increased capacity for the transmission of diseases such as dengue fever, malaria, and cholera, and threats to food security provide early warning of compounding negative health and nutrition effects if temperatures continue to rise. Adaptation, planning, and resilience for health Global inertia in adapting to climate change persists, with a mixed response from national governments since the signing of the Paris Agreement in 2015. More than half of global cities surveyed expect climate change to seriously compromise public health infrastructure, either directly, with extremes of weather disrupting crucial services, or indirectly, through the overwhelming of existing services with increased burdens of disease (indicator 2.2). Globally, spending for climate change adaptation remains well below the $100 billion per year commitment made under the Paris Agreement. Within this annual spending, only 3•8% of total development spending committed through formal UN Framework Convention on Climate Change (UNFCCC) mechanisms is dedicated to human health (indicator 2.8). This low investment in Panel 1: Progress towards the recommendations of the 2015 Lancet Commission on health and climate change In 2015, the Lancet Commission made ten policy recommendations. Of these ten recommendations, the Lancet Countdown is measuring progress on the following: Recommendation 1: invest in climate change and public health research Since 2007, the number of published articles on health and climate change in scientific journals has increased by 182% (indicator 5.2). Recommendation 2: scale up financing for climate-resilient health systems Spending on direct health adaptation as a proportion of total adaptation spending increased in 2017 to 4•8% (£11•68 billion), which is an increase in absolute and relative terms from the previous year (indicator 2.7). Health-related adaptation spending (including disaster response and food and agriculture) was estimated at 15•2% of total adaptation spend. Although this national-level spending is increasing, climate financing for mitigation and adaptation remains well below the US$100 billion per year committed in the Paris Agreement (indicator 2.8). Recommendation 3: phase out coal-fired power Coal consumption remains high, but continued to decline in 2017, a trend which is largely driven by China's decreased reliance and continued investment in renewable energy (indicators 3.2 and 3.3). The Powering Past Coal Alliance (an alliance of 23 countries including the UK, Italy, Canada, and France) was launched at the 23rd Conference of the Parties to the UN Framework Convention on Climate Change (UNFCCC) in December, 2017 (COP23), committing to phase out coal use by 2030 or earlier. Recommendation 4: encourage city-level low-carbon transition to reduce urban pollution In 2017, a new milestone was reached, with more than 2 million electric vehicles on the road, and with global per-capita electricity consumption for road transport increasing by 13% from 2013 to 2015 (indicator 3.6). C...

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Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus are commonly carried in the nasopharynx (NP) of young children, and have been speculated to interact with each other. Although earlier studies used cultures alone to assess these interactions, the addition of real-time quantitative polymerase chain reaction (qPCR) provides further insight into these interactions. We compared results of culture and qPCR for the detection of these three bacteria in 446 NP samples collected from 360 healthy young children in a prospective cohort study in the Peruvian Andes. Patterns of concurrent bacterial colonization were studied using repeated measures logistic regression models with generalized estimating equations. Spearman correlation coefficients were employed to assess correlations among bacterial densities. At a bacterial density <105 colony forming units (CFU)/ml measured by qPCR, culture detected significantly less carriers (P<0.0001) for all three pathogens, than at a bacterial density >105 CFU/ml. In addition, there was a positive association between S. pneumoniae and H. influenzae colonization measured by both culture (OR 3.11 – 3.17, p < 0.001) and qPCR (OR 1.95 – 1.97, p < 0.01). The densities of S. pneumoniae and H. influenzae, measured by qPCR, were positively correlated (correlation coefficient 0.32, p < 0.001). A negative association was found between the presence of S. pneumoniae and S. aureus in carriage with both culture (OR 0.45, p = 0.024) and qPCR (OR 0.61, p < 0.05). The impact of density on detection by culture and the observed density-related interactions support use of qPCR in additional studies to examine vaccine effects on diverse bacterial species.

The journal The Lancet recently published a countdown on health and climate change. Attention was focused solely on humans. However, animals, including wildlife, livestock and pets, may also be impacted by climate change. Complementary to the high relevance of awareness rising for protecting humans against climate change, here we present a One Health approach, which aims at the simultaneous protection of humans, animals and the environment from climate change impacts (climate change adaptation). We postulate that integrated approaches save human and animal lives and reduce costs when compared to public and animal health sectors working separately. A One Health approach to climate change adaptation may significantly contribute to food security with emphasis on animal source foods, extensive livestock systems, particularly ruminant livestock, environmental sanitation, and steps towards regional and global integrated syndromic surveillance and response systems. The cost of outbreaks of emerging vector-borne zoonotic pathogens may be much lower if they are detected early in the vector or in livestock rather than later in humans. Therefore, integrated community-based surveillance of zoonoses is a promising avenue to reduce health effects of climate change.