Generation Z is a digital native who was born together with and fluently using the internet. Research shows that most Generation Z gathering news from social medias. However, how much Generation Z trust the online news they read on official Instagram accounts has never been investigated before. The purpose of this study is determining the level of trust Generation Z giving in online news distributed through official Instagram accounts in the form of infographic and short news. The dependent variable is level of trust in online news and the independent variable is level of reading online news on official Instagram accounts. The independent variable is accounted by six indicators derived from attribution theory. This quantitative research focuses on Generation Z in Semarang City, Indonesia, especially undergraduate students at Diponegoro University with total 107 respondents. This research was conducted during the political campaign periods in Indonesia from February to April 2019 using questionnaires for simple random data sampling. Collected data was then analyzed with multiple regressions using SPSS. The results showed that the level of reading infographic news influenced 36,4% level of trust in online news; while it showed only 28,0% for the short news. However, despite the differences in the effect of reading levels on trust levels, the two groups of respondents showed the similar final level of trust in online news. Generation Z neither trusts online news in the form of infographics nor short news. They don't trust online news on Instagram regardless the form of the news.Generasi Z adalah generasi digital yang lahir bersama dan fasih menggunakan internet. Penelitian menunjukkan sebagian besar generasi Z mendapatkan berita dari media sosial. Namun, seberapa besar kepercayaan yang diberikan generasi Z pada berita daring yang mereka baca di akun resmi Instagram belum pernah diteliti sebelumnya. Tujuan penelitian ini adalah menentukan tingkat kepercayaan generasi Z terhadap berita daring yang dibaca melalui akun resmi Instagram dalam bentuk infografis dan bentuk berita ringkas. Variabel dependen adalah tingkat kepercayaan terhadap berita daring dan variabel independen adalah tingkat membaca berita daring di akun resmi Instagram. Variabel independen dipengaruhi oleh enam indikator yang diturunkan dari teori atribusi. Penelitian kuantitatif ini berfokus pada generasi Z di Kota Semarang, Indonesia, khususnya mahasiswa program sarjana Universitas Diponegoro dengan jumlah responden sebanyak 107 mahasiswa. Penelitian ini dilakukan selama masa kampanye politik di Indonesia pada bulan Februari hingga April 2019 dengan teknik pengambilan sampel dilakukan secara acak-sederhana menggunakan kuisioner. Data yang diperoleh kemudian dianalisis dengan regresi linear menggunakan aplikasi SPSS. Hasil penelitian menunjukkan bahwa tingkat membaca berita infografis mempengaruhi 36,4% tingkat kepercayaan terhadap berita online; sedangkan untuk berita ringkas hanya menunjukkan pengaruh sebesar 28,0%. Namun, meskipun terdapat perbedaan pengaruh tingkat membaca terhadap tingkat kepercayaan, kedua kelompok responden menunjukkan hasil akhir tingkat kepercayaan yang hampir sama pada berita daring. Generasi Z tidak mempercayai berita daring dalam bentuk infografis maupun berita ringkas. Mereka tidak mempercayai berita daring di Instagram terlepas dari apa bentuk beritanya.
ABSTRAKEmulsi minyak hati ikan kod dipercaya membantu mencegah pembentukan asam urat. Penelitian ini bertujuan mengkaji aktivitas antihiperurisemia secara in vivo dan mengembangkan metode antihiperurisemia secara in vitro emulsi minyak hati ikan kod. Metode in vivo dilakukan menggunakan mencit Swiss Webster jantan yang diinduksi makanan tinggi purin 100 mg/kg BB suspensi hati ayam, bersama pemberian sediaan pembanding atau sediaan uji selama 20 hari. Kelompok kontrol sakit menerima induksi. Kelompok pembanding alopurinol menerima induksi dan 26 mg/kg BB alopurinol. Kelompok pembanding vitamin A menerima induksi dan 650 IU/kg BB vitamin A. Kelompok uji dosis rendah, sedang, dan tinggi menerima induksi dan 150 mg/kg BB, 300 mg/kg BB, dan 450 mg/kg BB emulsi minyak hati ikan kod. Efek antihiperurisemia terbesar ditunjukkan dosis 150 mg/kg BB dengan penurunan kadar asam urat sebesar 57,04% dibanding kelompok kontrol sakit. Hasil percobaan in vivo menunjukkan emulsi minyak hati ikan kod yang diberikan bersamaan induksi makanan tinggi purin memiliki efek antihiperurisemia. Metode in vitro dilakukan menggunakan asam urat dan basa purin murni yang ditambahkan homogenat hati tikus sebagai sumber enzim xantin oksidase. Hasil percobaan in vitro menunjukkan emulsi minyak hati ikan kod menguraikan asam urat dalam 0,525 mL medium campuran 0,075 mg asam urat dan 0,011 mL emulsi minyak hati ikan kod; emulsi minyak hati ikan kod mencegah pembentukan asam urat dari purin dalam 0,725 mL medium campuran 0,200 mg purin, 0,066 gram homogenat hati, dan 0,016 mL emulsi minyak hati ikan kod.Kata kunci : antihiperurisemia, emulsi minyak hati ikan kod, asam urat, purin. ABSTRACTCod liver oil emulsion is believed of being able to prevent uric acid accumulation. This research was held to examine antihyperuricemic activity with in vivo and develop antihyperuricemic method with in vitro of cod liver oil emulsion. In vivo method was accomplished using Swiss Webster male mice inducted with high purine meal 100 mg/kg BW chicken liver suspense, together with drugs or cod liver oil emulsion through 20 days. Control group consumed high purine meal. Allopurinol group consumed high purin meal and 26 mg/kg BW of allopurinol. Vitamin A group consumed high purine meal and 650 IU/kg BW of vitamin A. Low dose, medium dose, and high dose group consumed high purine meal and 150 mg/kg BW, 300 mg/kg BW, and 450 mg/kg BW of cod liver oil emulsion. Strongest antihyperuricemic capability was shown by dose of 150 mg/kg BW with 57,04% degradation of uric acid compared to control group. In vivo showed that cod liver oil emulsion given together with high purine meal had antihyperuricemic effect. In vitro method was accomplished using pure uric acid and purine base with rat liver homogenate as xanthine oxidase enzyme source added. In vitro showed cod liver oil emulsion degraded uric acid in 0,525 mL medium mixture of 0,075 mg of uric acid and 0,011 mL cod liver oil emulsion; cod liver oil emulsion prevented uric acid establishment from purine in 0,725 mL medium mixture of 0,200 mg of purin, 0,066 gram of liver homogenate, and 0,016 mL of cod liver oil emulsion. Keywords : antihyperuricemic, cod liver oil emulsion, uric acid, purine.
Background: Worldwide, the prevalence of hyperuricemia has increased substantially in recent decades. The progressive increase in serum levels of uric acid levels may be linked to the rising prevalence of overweight and obesity, as well as the increase in consumption of sugar-sweetened beverages, foods rich in purines, and alcohol. Cod liver oil contains high levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as vitamins A and D. Many of the benefits of cod liver oil are believed to derive from its powerful anti-inflammatory properties. This study aimed to determine the effectiveness of cod liver oil emulsion as an anti-hyperuricemia agent in mice. Subjects and Method: This was an experiment conducted at the laboratory, Bandung Institute of Technology, in Bandung, West Java. A sample of 24 Swiss Webster rats was selected for this study, and was randomly assigned to 6 groups: (1) Uric acid induction with high purine food 100 mg/kg BW; (2) Uric acid induction and allopurinol 26 mg/kg BW dose; (3) Uric acid induction and vitamin A 650 IU/kg BW dose; (4) Uric acid induction and cod liver oil emulsion 150 mg/kg BW dose; (5) Uric acid induction and cod liver oil emulsion 300 mg/kg BW dose; and (6) Uric acid induction and cod liver oil emulsion 450 mg/kg BW dose. The independent variable was cod liver oil emulsion. The dependent variable was uric acid level. The data were analyzed by paired t test. Results: Cod liver oil emulsion of 150, 300, and 450 mg/kg BW doses reduced uric acid as much as 57.10%, 40.83%, and 49.70%. Conclusion:Cod liver oil emulsion of 150, 300, and 450 mg/kg BW doses are effective to reduce uric acid in mice.
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