This article is the result of the research "evaluation of hydrodynamic cavitation at laboratory scale for the disinfection of raw water in the municipality of Florencia-Caquetá", a study carried out at the facilities of the University of Amazonia - Macagual Research Headquarters between 2018 and 2019. This presents the results of hydrodynamic cavitation tests for the disinfection of filtered water in the municipality of Florencia, Caquetá. A removal of 98.62% of fecal coliforms was achieved for the greatest reduction of area in the venturi throat and pH 8.5, in a period of time of 60 minutes, this fact allows to determine that the technique is efficient, but it must be complemented with the use of disinfectant agents that present residual effect, the benefit is in the reduction of the dose of chemical disinfectant agent.