Increased physical activity is useful for reducing the risk of most non communicable diseases. However, the effect of high physical activity on hematological profile is not established yet. The aim of this study is to investigate the association of physical activity and hemoglobin concentration in college students. This cross-sectional study involved 67 male students
Background: Alcohol addiction has an acute and chronic impact, and may cause cognitive function impairment, in the form of interference in decision making and impulse control, as well as impaired motor function. Furthermore, research on alcohol addiction and cognitive function has not been widely studied in Indonesia. The purpose of this study was to explore the association between alcohol addiction and cognitive function among café visitors at South Jakarta. Methods: This was a cross sectional study, conducted among cafévisitors at South Jakarta in 2018. The respondents of this study were individuals who have consumed alcohol in the last 12 months and not consumed narcotics, psychotropic, and other addictive substances except nicotine and caffeine. Alcohol addiction among respondent was assessed by the CAGE questionnaire and cognitive function was assessed by the MoCA-Ina questionnaire. Statistical analysis was determined by Chi Square test. Results: In total, 80 respondents consisting of 57 men and 23 women met the study criteria, 67.5% of respondents have experienced alcohol addiction and 85.2% have experienced poor cognitive function. There was a strong association between alcohol addiction and cognitive function among café visitors (p=0.000; OR=44.083). Conclusions: Individual with alcohol addiction has a poor cognitive function compared with people without alcohol addiction. Therefore, awareness of the adverse effects of alcohol addiction on cognitive function among community is needed and thus, people are expected to distance from alcohol addiction.
Metastasis is the leading cause of mortality in patients with breast cancer. The molecular biology behind the metastasis is verycomplex and may require changes in the regulation of the cell cycle, protein that promotes autocrine growth loop, and the protein thatcauses epithelial to mesenchymal transition. More complex, it is clear that the biology of metastasis is partly governed by the non-tumourcells, including fibroblasts, endothelial cells and myoepithelial cells. Adrenomedullin is an autocrine growth factor produced by the renalcarcinoma cells. However, previous studies indicated that adrenomedullin can be secreted in various carcinoma tissue and carcinoma cells.Adrenomedullin may mediate immunosuppression, antiapoptosis, angiogenesis and proliferation, thus it is an important tumour cellsurvival factor underlying human carcinoma genesis. The role of adrenomedullin in the carcinoma genesis, invasion and metastasis hasbeen greatly focused. The aim of this study was to determine the concentration of adrenomedullin in patients with metastatic breast cancer.A total of 64 patients with breast cancer aged 21–90 years (63 women and 1 man) in Jakarta has been participated in this study aftersigning informed consent. Metastasis was confirmed by examination of bone scanning. Concentrations of adrenomedullin were measuredby EnzymeLinked Immunosorbent Assay (ELISA) using a commercial kit. Based on examination of bone scanning, there were 24 (37.5%)subjects with metastasis and 40 (62.5%) nonmetastasis. Mean of the concentrations of adrenomedullin in the subjects with metastasiswas 252.5 (205.0–299.9) pg/mL, while in the nonmetastasis was 203.1 (178.7–227.5) pg/mL. The concentrations of adrenomedullinwere significantly higher in subjects with metastasis than nonmetastasis (p=0.041). High concentration of adrenomedullin in the subjectswith metastasis suggests that adrenomedullin may be more likely to be involved in metastasis.
Pendahuluan: Dermatitis Atopik (DA) merupakan inflamasi pada kulit yang ditandai dengan peradangan kronis residif disertai gatal. Mekanisme inflamasi dan banyak reaksi imunitas dalam tubuh terlibat dalam DA. Pemeriksaan penunjang yang dapat dilakukan untuk mendiagnosis DA, di antaranya rasio neutrofil terhadap limfosit (NLR), rasio monosit terhadap limfosit (MLR), dan jumlah relatif eosinofil yang efektif, murah, dan mudah. Penelitian ini bertujuan untuk mengetahui peranan NLR, MLR, dan jumlah relatif eosinofil pada DA, serta mengetahui sensitivitas dan spesifisitasnya.Metode: Metode penelitian potong lintang dengan menggunakan apusan darah tepi. Jumlah sampel yang diambil sebanyak 61 pasien DA yang telah memenuhi kriteria inklusi dan eksklusi serta 61 kontrol sehat. Kemudian data dianalisis dengan uji normalitas Komolgorov-Smirnov dan Saphiro-Wilk serta uji statistik T tidak berpasangan, Mann-Whitney U dengan SPSS.Hasil: Hasil analisis data menunjukkan hubungan yang tidak bermakna antara NLR pasien DA dan kontrol sehat, p=0,858. Hasil penelitian juga menunjukkan hubungan yang bermakna antara MLR dan jumlah relatif eosinofil pada pasien DA dan kontrol sehat dengan nilai p=0,000 dan p=0,013. Nilai cut-off MLR dan jumlah relatif eosinofil masing-masing <0,0488 (sensitivitas 70,5%, spesifisitas 72,1%, AUC 75,2%) dan >2,25 (sensitivitas 70,5%, spesifisitas 77%, AUC 78%).Kesimpulan: MLR dan jumlah relatif eosinofil dapat diusulkan sebagai alat diagnostik untuk membantu penegakkan diagnosis DA, namun NLR tidak dapat dijadikan alat diagnostik DA.
Protein disulfide isomerase (PDI) is a member of thioredoxin superfamily that is secreted in the lumen of the endoplasmic reticulum (ER) in mammalian cells. PDI catalyzes disulfide bond formation, reduction, or isomerization of newly synthesized proteins in the lumen of the RE. PDIA4 is a member of the PDI family, which is also expressed in the mammary gland. Low expression of PDIA4 probably as a result of the stress of RE in hypoxic conditions. These conditions will enhance the ability of tumor cells in mammary tissue to divide aggressively and metastasize. A total of 61 breast cancer patients aged 23−90 years (60 women and 1 man) in Jakarta, Indonesia have participated in this study after signing the informed consent letter. The diagnosis of metastasis is confirmed by the examination of bone scanning. Measurement of PDIA4 concentration is performed by the quantitative enzyme-linked immunosorbent assay (ELISA) using a commercial kits. Based on the examination of the bone scanning, there were 23 (62.5%) subjects with metastatic and 38 (37.5%) subjects non-metastatic. The mean of age of the subjects with metastatic were significantly higher than non-metastatic subjects (p=0.028), which is 51.4 (45.9–56.8) and 44.2 (40.4–48.0). The median of PDIA4 concentrations in serum of subjects with metastatic, i.e. 7.7 (1.0–37.2) ng/ml was significantly lower than non-metastatic subjects (p=0.044), i.e. 9.4 (2.2–69. 6) ng/mL. The concentration of PDIA4 in serum of breast cancer patients with metastatic were significantly lower than non-metastatic patients. It shows that the concentration of PDIA4 have decreased in incidence of metastatic breast cancer.
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