The 18SIB04 QuantumPascal EMPIR project aims for development of photon-based standards that can replace primary standards of the SI unit of pressure, the Pascal. In this project, four partners simulated the pressure-induced deformation of a given Fabry-Pérot cavity, using various versions of two types of software, COMSOL Multiphysics (R) and ANSYS Workbench. It was demonstrated that, for a given geometry and set of material parameters, simulations of the deformation could be performed by the various partners with such small discrepancies that methodological mistakes of the simulation procedures will solely contribute to a sub-ppm uncertainty in the assessments of refractivity of N<sub>2</sub>.
Background and Aim. Lung ultrasound (LUS) is a convenient imaging modality in the setting of coronavirus disease-19 (COVID-19) because it is easily available, can be performed bedside and repeated over time. We herein examined LUS patterns in relation to disease severity and disease stage among patients with COVID-19 pneumonia. Methods. We performed a retrospective case series analysis of patients with confirmed SARS-CoV-2 infection who were admitted to the hospital because of pneumonia. We recorded history, clinical parameters and medications. LUS was performed and scored in a standardized fashion by experienced operators, with evaluation of up to 12 lung fields, reporting especially on B-lines and consolidations. Results. We included 96 patients, 58.3% men, with a mean age of 65.9 years. Patients with a high-risk quick COVID-19 severity index (qCSI) were older and had worse outcomes, especially for the need for high-flow oxygen. B-lines and consolidations were located mainly in the lower posterior lung fields. LUS patterns for B-lines and consolidations were significantly worse in all lung fields among patients with high versus low qCSI. B-lines and consolidations were worse in the intermediate disease stage, from day 7 to 13 after onset of symptoms. While consolidations correlated more with inflammatory biomarkers, B-lines correlated more with end-organ damage, including extrapulmonary involvement. Conclusions. LUS patterns provide a comprehensive evaluation of patients with COVID-19 pneumonia that correlated with severity and dynamically reflect disease stage. LUS patterns may reflect different pathophysiological processes related to inflammation or tissue damage; consolidations may represent a more specific sign of localized disease, whereas B-lines seem to be also dependent upon generalized illness due to SARS-CoV-2 infection.
The INRiM static expansion system has been recently modified in order to improve its performance and extend the working range down to 5.10-4 Pa. A new characterization of the system has been performed and a preliminary estimate of the uncertainty has been evaluated.
This report describes a EURAMET bilateral supplementary comparison between Czech CMI and Italian INRIM in low negative gauge pressure in gas (nitrogen), denoted as EURAMET.M.P-S12.
The digital non-rotating pressure balance FPG8601 manufactured by Fluke/DH-Instruments, USA is normally used for gauge and absolute pressures in the range from 1 Pa to 15 kPa, but with some modifications it can be used also for the negative gauge pressures in the same range.
During the preparation of the visit of INRIM at CMI for the last comparison within the framework of EURAMET.M.P-K4.2010, it was agreed to also perform an additional comparison in the range from 300 Pa to 15 kPa of negative gauge pressure. The measurements were performed in October 2012.
Both institutes successfully proved their equivalence in all the tested points in the range from 300 Pa to 15 kPa of negative gauge pressure in a comparison that had, so far, been unique.
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To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
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