The present work describes the development of an improved synthesis of active pharmaceutical ingredient raltegravir. The isolation of a new process intermediate and the newly developed conditions solve the issue of selectivity typical of this production process, with no need for the use of protecting groups, making the present route more efficient and sustainable than what was reported before. Efficiency comparisons with the previous processes confirm the result here obtained.

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This paper addresses the analysis of the gear shifting maneuver for motorcycles and it constitutes, to our best knowledge, the first contribute to study this aspect in twowheeled vehicles. Specifically, a comparison between automatic and manual gear shifting is discussed, based on which some cost functions are proposed to quantitatively evaluate the maneuver quality from measured data. Based on such cost functions, we are able to automatically classify the performed maneuver and label it with a quality attribute matching that assigned by the rider.

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