Calibration of flow devices is important in several areas of pharmaceutical, flow chemistry and microfluidic applications where dosage of process liquids or accurate measurement of the flow rate is important. The process-oriented liquid itself might influence the performance of the flow device and the simultaneous determination of the dynamic viscosity under flow conditions might be a valuable information for the process parameters. To offer the simultaneous calibration of the dynamic viscosity of the process-oriented liquid at the corresponding flowrate, METAS has built a pipe viscometer for the traceable in-line measurement of the dynamic viscosity in the current flow facilities for low flow rates from 1 L/min to 150 mL/min and pressure drops up to 10 bar. The traceability of all the measuring quantities as well as the geometrical dimensions of the micro tube guarantee the traceability of the pipe viscometer to SI units. The most challenging part is the traceable determination of the inner diameter of the micro tube. This can be achieved by measuring the pressure drop as a function of flow rate with the pipe viscometer and applying the law of Hagen-Poiseuille with a traceable dynamic viscosity of a reference liquid (water) or perform the measurements with the micro-CT at METAS, which determines the inner diameter by x-ray diffraction. The validation of the stated measurement uncertainty of the pipe viscometer has been performed by means of calibration of the dynamic viscosity of several reference liquids with traceable density and kinematic viscosity. The setup of the facility, the traceability as well as the uncertainty calculation of the pipe viscometer for the in-line measurement of the dynamic viscosity are discussed in this paper.
Calibration of flow devices is important in several areas of pharmaceutical, flow chemistry and microfluidic applications where dosage of process liquids or accurate measurement of flow rate is important. The process-oriented liquid itself might influence the performance of a flow device and the simultaneous determination of dynamic viscosity under flow conditions might provide valuable information for process parameters. To offer simultaneous calibration of the dynamic viscosity of a process-oriented liquid at the corresponding flowrate, METAS built a pipe viscometer for the traceable inline measurement of dynamic viscosity in current flow facilities for low flowrates from 1 μL/min to 150 mL/min and pressure drops up to 10 bar. The traceability of all measuring quantities as well as geometrical dimensions of the microtube guarantee the traceability of the pipe viscometer to SI units. The most challenging part is the traceable determination of the inner diameter of the microtube. This can be achieved by measuring the pressure drop as a function of flowrate using a pipe viscometer and applying the Hagen–Poiseuille law with a traceable dynamic viscosity of a reference liquid (water) or performing measurements by utilizing the μ-CT facility at METAS, where the inner diameter is determined using X-ray diffraction. The validation of the stated measurement uncertainty of the pipe viscometer was performed by calibrating the dynamic viscosity of several reference liquids with traceable density and kinematic viscosity. The setup of the facility, traceability as well as uncertainty calculation of the pipe viscometer for inline measurement of dynamic viscosity are discussed in this paper.
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