Keywords • confocal laser scanning microscopy • in vivo • dermatoscopy • nevus • melanoma • basal cell carcinoma • squamous cell carcinoma Zusammenfassung Seit einigen Jahren findet die in vivo konfokale Laser-Scanning-Mikroskopie (confocal laser scanning microscopy, CLSM) in der nichtinvasiven Diagnostik der Haut zunehmend Verbreitung. Sie ermöglicht die Darstellung mikroanato-mischer Hautstrukturen in Echtzeit. Mögliche Einsatzgebiete sind unter ande-rem die Diagnostik klinisch schwer einzuordnender Hauttumoren und die präoperative Einschätzung der Tumorausdehnung. Durch zusätzliche Informa-tionen über zelluläre Veränderungen mittels In-vivo-CLSM können Biopsien und Operationen teilweise vermieden werden. Für verschiedene Hauttumoren wurde eine Vielzahl konfokalmikroskopischer Diagnosekriterien publiziert. Mit der vorliegenden Übersichtsarbeit wollen wir einen Überblick über die Me-thode und die diagnostischen Kriterien der In-vivo-CLSM der Haut geben. Wir vergleichen Sensitivität und Spezifität der bereits publizierten Kriterien mit ei-genen Erfahrungen beim klinischen Einsatz an 100 Tumoren. In Kombination mit der klinischen Untersuchung und der Dermatoskopie erweist sich die in vivo konfokale Laser-Scanning-Mikroskopie als nützliche Methode für die Dia-gnostik von Hauttumoren. Summary In recent years, in vivo confocal laser scanning microscopy (CLSM) has become an established method for the non-invasive examination of the skin. In vivo CLSM allows for real-time imaging of micro-anatomic cutaneous structures. It has been used to diagnose ambiguous skin tumors and to measure subclinical tumor spread prior to surgery. By additionally providing high power morphologic information , in vivo CLSM helps to reduce unnecessary biopsies. A multitude of diagnostic features for skin tumors has been published. Here we review published diagnostic in vivo CLSM features, and compare them to our own experience in 100 tumors. In combination with clinical examination and dermatoscopy, in vivo CLSM is a valuable additional tool for non-invasive skin tumor diagnosis.
SummaryIn recent years, in vivo confocal laser scanning microscopy (CLSM) has become an established method for the non-invasive examination of the skin. In vivo CLSM allows for real-time imaging of micro-anatomic cutaneous structures. It has been used to diagnose ambiguous skin tumors and to measure subclinical tumor spread prior to surgery. By additionally providing high power morphologic information, in vivo CLSM helps to reduce unnecessary biopsies. A multitude of diagnostic features for skin tumors has been published. Here we review published diagnostic in vivo CLSM features, and compare them to our own experience in 100 tumors. In combination with clinical examination and dermatoscopy, in vivo CLSM is a valuable additional tool for non-invasive skin tumor diagnosis.
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