Fused pyrimidine derivatives R 0515 Synthesis and Evaluation of 7-Amino-2-(2(3)-furyl)-5-phenylethylamino-oxazolo[5,4-d]pyrimidines as Potential A2A Adenosine Receptor Antagonists for Positron Emission Tomography (PET). -A variety of the title oxazolopyrimidines (XIII) (10 examples) is synthesized which show affinities for the A2AAR in the low--nanomolar range. However, these compounds are no promising PET ligands due to a rather unspecific binding. -(HOLSCHBACH*, M. H.; BIER, D.; STUESGEN, S.; WUTZ, W.; SIHVER, W.; COENEN, H. H.; OLSSON, R. A.; Eur. J. Med. Chem. 41 (2006) 1, 7-15; Inst. Nuklearchem., Forschungszent.
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