Objective: To investigate relationships between individuals' socioeconomic situations and quality of life in working-aged subjects with Parkinson's disease. Methods: A population-based cohort comprising 1,432 people with Parkinson's disease and 1,135 matched controls, who responded to a questionnaire. Logistic regression analysis was performed to identify factors associated with life satisfaction and likelihood of employment. Results: In multivariate analyses, Parkinson's disease was associated with an increased risk of dissatisfaction with life (odds ratio (OR) = 5.4, 95% confidence interval (95% CI) = 4.2-7.1) and reduced likelihood of employment (OR = 0.30, 95% CI = 0.25-0.37). Employers' support was associated with greater likelihood of employment (p < 0.001). Twenty-four percent of people with Parkinson's disease for ≥ 10 years remained employed and 6% worked full-time. People with Parkinson's disease also more frequently experienced work demands that exceeded their capacity; this factor and unemployment independently correlated with greater risk of dissatisfaction with life (both p < 0.05). Conclusion: People with Parkinson's disease have an increased risk of dissatisfaction with life. Employment situation is important for general life satisfaction among workingaged individuals. People with Parkinson's disease appear to find it difficult to meet the challenge of achieving a balanced employment situation.

Objective: To evaluate maximal isometric muscle force at 18 years of age in relation to Parkinson disease (PD) later in life.Methods: The cohort consisted of 1,317,713 men who had their muscle strength measured during conscription . Associations between participants' muscle strength at conscription and PD diagnoses, also in their parents, were examined using multivariate statistical models. Parkinson disease (PD) is a progressive neurodegenerative disease resulting primarily from the cell death of dopaminergic neurons in the substantia nigra, which produces the cardinal symptoms of bradykinesia, rigidity, and tremor. Results