Malignant hyperthermia can result from mutations in the ryanodine receptor that favor anesthetic-induced Ca2+ release. Zullo et al. find that membrane potential modulates the effect of the volatile anesthetic halothane on skeletal muscle ryanodine receptors possessing the Y524S mutation.
41 C/1h): interestingly mortality rate was dramatically decreased in trained (t) CASQ1-null mice compared to un-trained (un-t) controls: 16% vs. 86%, respectively. In tCASQ1-null mice, the increase in core temperature during exposure to heat-stress (i.e. hyperthermia) was lower than in un-t mice, and their EDL muscles displayed a lowered threshold of response when exposed to increasing [caffeine] during in-vitro contracture test (IVCT). Several other parameters were assessed in muscle samples: aerobic training succeeded in decreasing mitochondrial damage (14.853.9% vs. 752.3%), mitochondrial efficiency by increasing of 34% the cytochrome-c oxidase activity, while decreasing SERCA's and also Ca 2þ -dependent proteolytic activity. Additionally, training also reduced lipid peroxidation (elevated in un-tCASQ1-null mice) in isolated sarcoplasmic reticulum and mitochondria membranes: À45 and À35 %, respectively. In conclusion, aerobic training protects CASQ1null mice from HS, an effect essentially mediated by a significant reduction in oxidative stress and fiber damage.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.