33In Down syndrome (DS), the overall genetic imbalance caused by trisomy of chromosome 21 leads to a 34 complex pleiotropic phenotype that involves a recognizable set of facial traits. Several studies have 35shown the potential of epigallocatechin-3-gallate (EGCG), a green tea flavanol, as a therapeutic tool for 36 alleviating different developmental alterations associated with DS, such as cognitive impairment, skull 37 dysmorphologies, and skeletal deficiencies. Here we provide for the first time experimental and clinical 38 evidence of the potential benefits of EGCG treatment to facial morphology. Our results showed that 39 mouse models treated with low dose of EGCG during pre-and postnatal development improved facial 40 dysmorphology. However, the same treatment at high dose produced disparate facial morphology 41 changes with an extremely wide and abnormal range of variation. Our observational study in humans 42 revealed that EGCG treatment since early in development is associated with intermediate facial 43phenotypes and significant facial improvement scores. Overall, our findings suggest a potential 44 beneficial effect of ECGC on facial development, which requires further research to pinpoint the optimal 45 dosages of EGCG that reliably improve DS phenotypes. Current evidence warns against the non-46 prescribed intake of this supplement as a health-promoting measure. 47 48 Introduction 49
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.