The pathophysiology of respiratory failure associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains under investigation. One hypothesis is that progressive endothelial damage from the virus leads to microvascular thrombosis. It is uncertain if empiric therapeutic anticoagulation provides benefit over standard deep vein thrombosis (DVT) prophylaxis in critically ill patients with SARS-CoV-2. A retrospective cohort study was performed to evaluate adult patients admitted to the intensive care unit at 3 hospitals with polymerase chain reaction-confirmed SARS-CoV-2-associated respiratory failure requiring invasive mechanical ventilation. A Kaplan-Meier survival analysis was used to compare patients who were initiated on therapeutic anticoagulation prior to the time of intubation and those receiving standard DVT prophylaxis doses. The primary outcome was the difference in the 28-day mortality of patients between the 2 groups. Twenty-eight-day mortality did not differ between groups, occurring in 26.1% of patients who received therapeutic anticoagulation and 29.5% of those who received a prophylactic dose only (hazard ratio, 0.52; P = .055). There was no difference in 28-day mortality between groups in patients who were admitted with a serum D-dimer ≥ 2 μg/mL (hazard ratio, 0.67; P = .41). Empiric therapeutic anticoagulation in patients who require invasive mechanical ventilation for confirmed SARS-CoV-2 infection does not improve 28-day mortality compared with standard DVT prophylaxis, even among those with elevated D-dimer levels.
Paenibacillus alvei (formerly Bacillus alvei) is infrequently recognized as a pathogenic bacterium in humans. P. alvei has historically been considered a nonvirulent organism found in soil and water sources and most well-described in European foulbrood, a disease of honeybees. Few case reports have been described in humans, none of which include cavitary lung abscess formation. We describe a case of multifocal lung abscesses secondary to P. alvei in an immunocompetent man and review the literature of other case reports in humans. Identification of P. alvei remains challenging, and the biochemical tests to make the diagnosis are reviewed. Treatment is generally guided by in vitro susceptibility patterns, and we will review the clinical case reports that have resulted in successful treatment of this bacterium.
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