Bone
metastasis occurs in the majority of cancer patients, which
hampers quality of life and significantly decreases survival. Aggressive
chemotherapy is a traditional treatment regimen that induces severe
systemic toxicities. Therefore, bone-directed therapies are highly
warranted. We report a novel nanoparticle formulation that is composed
of poly(vinylpyrrolidone) and tannic acid core nanoparticles (PVT
NPs) that forms self-assembly with zoledronic acid (ZA@PVT NPs). The
construction of ZA@PVT NPs was confirmed by particle size, zeta potential,
transmission electron microscopy, and spectral analyses. An optimized
bone-targeted ZA@PVT NPs formulation showed greater binding and internalization
in in vitro with metastasis prostate and breast cancer cells. ZA@PVT
NPs were able to deliver ZA more efficiently to tumor cells, which
inhibited proliferation of human prostate and breast cancer cells.
In addition, ZA@PVT NPs were capable of targeting mouse bones and
prostate tumor microarray tissues (ex vivo) while sparing all other
vital organs. More importantly, ZA@PVT NPs induce chemo sensitization
to docetaxel treatment in cancer cells. Overall, the study results
confirm that ZA-based, bone-targeted NPs have great potential for
the treatment of bone metastasis in the near future.
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