This paper describes the development
of Pd-catalyzed inter- and
intramolecular direct arylation using mesylates. Furthermore, a sequential
mesylation/arylation protocol using phenols as substrates is described.
These transformations are general with respect to the electronics
of the C–H substrates and allow for the synthesis of diverse
heterocyclic motifs in good yields. Both arenes and heteroarenes efficiently
participate in these reactions. Preliminary mechanistic studies are
presented for both inter- and intramolecular arylations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.