A Cs 2 CO 3 -catalyzed azide-acetonitrile [3+2]-cycloaddition reaction of monosubstituted acetonitriles with aryl azides has been developed for the synthesis of 5-amino-1,2,3-triazoles.
Azide-Acetonitrile "click" Reaction Triggered by Cs 2CO3: The Atom-Economic, High-Yielding Synthesis of 5-Amino-1,2,3-triazoles. -Tosyl azide does not react under the given conditions to yield the desired product. By varying base and conditions, cascade click reactions can be performed chemoselectively, e. g. to give compound (XIII). -(KRISHNA, P. M.; RAMACHARY*, D. B.; PEESAPATI, S.; RSC Adv. 5 (2015) 76, 62062-62066, http://dx.doi.org/10.1039/C5RA12308A ; Catal. Lab., Sch. Chem., Univ. Hyderabad, Hyderabad 500 046, India; Eng.)-M. Tismer 48-153
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