A local Digital Volume Correlation (DVC) based measurement of displacements and strains of synthetic bone samples under an ex-situ compression using the time-lapsed imaging procedure was performed in the present study. Micro Finite Element (µFE) model was used to simulate the compression of synthetic bone samples with experimental-based ( ExBC), and DVC interpolated displacement boundary conditions ( IPBC). The obtained µFE nodal displacement data compared with DVC. A good match of displacement patterns and correlation values of R2 = 0.85–0.99 and RMSE ≤ 12 µm was observed for the IPBC predicted displacements against DVC displacements. However, the ExBC provided a good correlation of transverse displacements only (U: R2 = 0.85–0.99 and V: R2 = 0.77–0.99). The average axial displacement of ExBC matched well with DVC, and a qualitative and quantitative understanding of the axial displacement was possible with ExBC. A moderate agreement of axial strain patterns was observed between DVC and IPBC, even though a good agreement on displacement was observed. The ExBC showed a higher axial strain compared to DVC in all samples. The transverse strains varied between the same extreme values for both boundary conditions and within the DVC range.
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