other methods derived from miscellaneous synthons towards the total synthesiso fn on-peptidic macrolides.T he synthetic routes and the key strategies involved in the total syntheses of ten natural macrolides have been discussed. Both the amino acid-derived and non-amino acid-derived synthetic routes have been illustratedt op resentacomparative study between the two approaches.Scheme3.Prusov's approach towards the total synthesis of Ripostatin B( 5).Scheme4.To tal synthesis of Ripostatin B( 5)b yA ltmann's approach. Figure 3. Biologically active analogues of Ripostatin.
The route to biologically active xanthone and fluorenone analogs proceeds smoothly for substrates equipped with electron‐donating substituents, but leads to no reaction or trace amounts of products for substrates with electron‐withdrawing groups.
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