Isatin is an endogenous compound and possess a wide variety of biological activities. In the present investigation, a different isatin derivatives such as novel isatin 3-[N-(4-substituted)-hydrazinyl-3-oxo prop 1-en-2yl) benzamides and their antimicrobial, analgesic and anticonvulsant activity was evaluated in different animal models. Antimicrobial activity by cup plate agar diffusion method. The analgesic activity was measured by Eddy's hot plate method, and reaction time was recorded when the animals licked their for and hind paws and jumped at before 0 hr, 0.5 hr, 1 hr and 2 hrs after administration of test drugs. 4-aminopyridine chemical induction method was employed for anticonvulsant activity. All the compounds were screened, among the screened compounds some compounds showed antimicrobial, analgesic and anticonvulsant activity with dose-dependent effect when compared with the control group.
Objective: The aim of this study to synthesize, characterize and screen some new isatin derivatives for their antimicrobial activities. Method: A library of isatin derivatives were synthesized, structures of newly synthesized compounds were deduced based on spectral data and elemental analysis. Results: Antibacterial activity was screened against gram positive and gram negative bacterial strains. Conclusion: The novel isatin derivatives produce significant antimicrobial activities.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.