The aim of the current study is to explore the effects of heat and mass transfer on unsteady chemically reacted Casson liquid flow over an exponentially accelerated vertical plate in a porous medium. It is assumed that the bounding plate has varying temperatures as well as concentrations in a porous medium under a uniform magnetic field. This phenomenon is modeled in the form of a system of partial differential equations (PDEs) with boundary conditions. The governing dimensionless PDEs are solved using Laplace transform method for velocity, temperature, and concentration. The impact of nondimensional parameters, which are controlling the flow like Casson parameter, Soret number, magnetic parameter, heat generation parameter, Prandtl number, radiation parameter, and Schmidt number is analyzed through graphs. The incremental values of the Casson fluid parameter lead to a reduction in velocity and discovered that for large values of the Casson parameter, the fluid is near to the Newtonian fluid. Also, the Sherwood number increases with enhancing dissimilar estimators of the Schmidt and Soret numbers. A comparison has been made with the published work (Kataria et al.) for a particular case, which was in good agreement.