Nutraceutical-based interventions hold promise to reduce blood pressure (BP) and arterial stiffness, which are two cardiovascular disease (CVD) risk factors. However, the effects of coconut sap powder (CSP), an Asian sweetener and novel nutraceutical, on BP and arterial stiffness in middle-aged and older adults (MA/O, ≥ 45 y) has yet to be established. We hypothesized CSP will decrease BP and arterial stiffness in MA/O adults. In a double-blind, randomized, placebo-controlled study design, nineteen (age 55.3 ± 2.1 y) MA/O adults completed measures of brachial and carotid BP, and arterial stiffness (carotid-femoral pulse wave velocity [cfPWV], common carotid artery (CCA) β-stiffness, compliance, distensibility, and Young's and Peterson's Elastic moduli) before and after 8 weeks of CSP (1.5 g/day) or placebo (1.5 g/day). A two-way repeated measures analysis of variance was used to compare group mean differences. Compared to placebo, CSP lowered brachial systolic BP (SBP) (CSP pre: 117.4 ± 2.9 vs post: 109.0 ± 2.4 mmHg, p<0.05), but not carotid SBP (p=0.12). CSP also lowered Youngs (CSP pre: 5514.4 ± 1115.4 vs post: 3690.6 ± 430.9 kPa) and Peterson's Elastic moduli (CSP pre: 22.2 ± 4.4 vs post: 19.2 ± 4.5 kPa) (p<0.05, both). A trend for CSP to lower CCA β-stiffness (p=0.06) and increase CCA compliance (p=0.07) was also observed. Arterial stiffness assessed by cfPWV did not change (p>0.05). No inflammatory or antioxidant biomarkers were affected by CSP. In summary, 8 weeks of CSP lowers brachial SBP and CCA mechanical stiffness indicating a potential cardioprotective effect in MA/O adults.
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