This cross-sectional study has been conducted in a descriptive, correlational design in order to determine the correlation between sexual satisfaction and depressive symptoms. In this respect, sexual satisfaction and depression scores were assessed in 102 infertile couples in a Turkish university hospital. There was a positive and meaningful correlation between Beck Depression scores and educational status and monthly income of infertile women on the one hand, and among marriage, infertility, infertility treatment durations, and the number of assisted-reproduction treatments on the other hand. It was found that there were more sexual dysfunctions in women than in men and that they were affected more deeply. As a result, it might be suggested that infertile couples receive proper guidance from health professionals in the course of treatment.