One new and eight known ceanothane-and lupane-type triterpenes were isolated from the root bark of Ziziphus cambodiana PIERRE (Rhamnaceae). Based on spectral analyses, the structure of the new compound was elucidated as 3-O-(4-hydroxy-3-methoxybenzoyl)ceanothic acid (3-O-vanillylceanothic acid) (1), while the known compounds were identified as lupeol (2), betulinaldehyde (3), betulinic acid (4), 2-O-E-p-coumaroyl alphitolic acid (5), alphitolic acid (6), zizyberanalic acid (7), zizyberenalic acid (8) and ceanothic acid (9). Compounds 1, 5 and 8 exhibited significant in vitro antiplasmodial activity against the parasite Plasmodium falciparum, with inhibitory concentration (IC 50 ) values of 3.7, 0.9 and 3.0 m mg/ml, respectively. Compounds 1 and 3-8 showed antimycobacterial activity against Mycobacterium tuberculosis with respective MIC values of 25, 25, 25, 12.5, 50, 50 and 100 m mg/ml.
Terpenes U 0200Ceanothane-and Lupane-Type Triterpenes with Antiplasmodial and Antimycobacterial Activities from Ziziphus cambodiana. -One new (I) and 8 known ceanothane-and lupane-type triterpenes are isolated from the root bark of Ziziphus cambodiana Pierre and their in vitro antiplasmodial activity against the parasite Plasmodium falciparum is studied. (I) exhibits significant (IC50 3.7) in vitro activity. -(SUKSAMRARN*, S.; PANSEETA, P.; KUNCHANAWATTA, S.; DISTAPORN, T.; RUKTASING, S.; SUKSAMRARN, A.; Chem.
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