Research into the pathophysiology of Alzheimer’s disease (AD) and Parkinson’s disease (PD) has spanned decades, unraveling deregulated signaling cascades in these diseases. Recently, the discovery of the link between ferroptosis and neurodegeneration has opened new avenues for neurodegenerative disease research. Despite this, the key players in the ferroptotic pathway potentially governing the progression of neurodegenerative disease remain unidentified. Thus, in the present study, we reconstructed two protein–protein interaction networks (PPINs) for AD and PD with their respective differentially expressed genes from post-mortem tissues and identified 21 highly connected clusters within the AD PPIN and 17 clusters within the PD PPIN. Then, we identified 8 ferroptotic transcription factors (FerrTFs) that regulate hub genes from the 7 deregulated clusters of AD and 6 FerrTFs from the 4 deregulated clusters of PD. Functional enrichment analysis of these clusters revealed impairment in important neurological functions. Finally, we identified 681 drugs with potential therapeutic effects against the 8 FerrTFs associated with AD and 633 drugs against the 6 FerrTFs linked to PD. In addition, 126 and 114 miRNAs might silence 7 and 5 FerrTFs against AD and PD, respectively. This exploratory study identifies potential markers of ferroptosis that could exacerbate these neurodegenerative diseases and also suggests possible therapeutic measures against them.
Pulses has the ability of withstanding extreme weather conditions, requires less water, has the capability of atmospheric nitrogen fixation, and is an affordable eminent replacement of animal proteins, especially for the economically weaker population. For a country like India, promising only around 47.9 g/capita/person/day of pulses of recommended 80 g/capita/person/day by National Institute of Nutrition (2011), the protein on the plate is not sufficient for sure. India, standing second in worldwide lentil production, in 2017-18 had the highest production of lentils between 2010-11 to 2019-20. Our analysis strongly depicts that in the decade (2010-11 to 2019-20) the production, import and export relation is not synchronised which robustly indicates that lentil cultivation, which seems to be in fair state, should be undoubtedly handled effectively to avoid threat in pulse circulation in India and globally. Also, before reaching any unprecedented agricultural hazard and to achieve total food security of lentils, it is obvious to look into the parameters which directly or indirectly affect lentil production and distribution throughout the country. Thus, we predict that efficacy of policy making of lentil security will have beneficial implementations on the economically deprived population in the rural India.
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