The advancement and future prospects of transition-metal-catalyzed auxiliary assisted regioselective C7-functionalization of indoles/indolines are covered in this article.

A weak carbonyl coordination facilitated tunable reactivity between alkenylation and alkylation of indoles at the C4 C–H site is presented using readily accessible allylic alcohols in the presence of Rh catalysis by switching the additives or directing group. Exclusive site selectivity, functional group tolerance, and late-stage modifications are the important practical features.

Dioxygenation of olefins is a valuable synthetic tool for the construction of 1,2‐diols and α‐oxygenated ketones. The use of radical approaches to achieve this direct 1,2‐difunctionalization has recently made considerable progress. The metal‐catalyzed reactions employ molecular oxygen and air as the oxidants, whereas metal‐free dioxygenation utilizes oxygen and peroxides. These oxidations are effective under mild conditions, with activated olefins found to be the most successful substrates. This microreview covers the recent developments in the radical dioxygenation of olefins, with respect to substrate scope, mechanism, and the advantages and disadvantages of the methods.

Strained ring systemsa re regarded as privileged coupling partnersi nd irected CÀHb ond functionalization and have emergeda sapotential research area in organic synthesis. The inherent ring strain in these systems acts as a driving force, allowing the facile construction of diversified structural scaffolds via integrating CÀHa ctivation and ringscission. The mechanistic underpinnings allows the implementation of ap lethora of CÀHb onds across plentiful or-ganic substrates, including the less reactive alkyl ones. Consideringt he synthetic space, this area will foster developments of novel synthetic methods in chelation guided CÀH functionalization. This review will focus on recent developments in transition-metal catalyzed chelation assisted concomitant CÀHa ctivation and ring scissiono fs trained rings to attain molecular complexity. Figure 1. Strained rings/carbocycles vs. heterocyclic counterparts.[a] Dr.

A copper-mediated picolinamide directed regioselective cross-coupling of naphthylamines with azoles is developed via C-H functionalization and C-N bond formation. The reaction of indoles leads to the formation of chiral C-N cross-coupled products with functional group tolerance. These reaction conditions can also be extended to the cross-coupling of pyrazole and pyrrole scaffolds.