Polyaromatic amphiphilic probes have been developed, that can be involved in the chromogenic detection of Cu+ ions in the anionic micelle. A rapid change in solution color from yellow to...
An
easily synthesizable pyrene-based amphiphilic probe (Pybpa) has been developed, which exhibited no responses with metal ions
in the pure aqueous medium despite possessing a metal ion-chelating
bispicolyl unit. We believe that spontaneous aggregation of Pybpa in aqueous medium makes the ion binding unit not accessible
to the metal ions. However, the sensitivity and selectivity of Pybpa toward Zn2+ ions drastically improve in the
presence of serum albumin protein, HSA. The differences in the microenvironment
inside the protein cavity, in terms of local polarity, and conformational
rigidity might be attributing factors for that. The mechanistic investigations
also suggest that there might be the involvement of polar amino acid
residues that take part in coordination with Zn2+ ions. Pybpa shows no detectable spectroscopic changes with Zn2+ ions in aqueous medium in the absence of HSA. However, it
can effectively recognize Zn2+ ions in the protein-bound
form. Moreover, the photophysical behavior of Pybpa and
its zinc complex have been investigated with DFT and docking studies.
Noteworthy, such an unusual sensing aspect of Zn2+ exclusively
in the protein-bound state and particularly in aqueous medium is truly
rare and innovative.
In this paper, we report the synthesis and structural characterisation of two hetero-metallic clusters, [(CO)3CrSn5Cr(CO)3]4‒ and [(CO)3MoSn5Mo(CO)3]4‒, both of which have a pentagonal bipyramidal core. The structures are similar to that of previously reported [(CO)3MoPb5Mo(CO)3]4‒ and our analysis of the bonding suggests that they are best formulated as containing Sn54- rings bridging two zerovalent M(CO)3 fragments. The electronic structure is compared to two isolobal M2E5 clusters, [CpCrP5CrCp]- and Tl77-, both of which show clear evidence for trans-annular bonds between the apical atoms that is not immediately obvious in the title clusters. Our analysis shows that the balance between E-E and M-M bonding is a delicate one, and shifts in the relative energies of the orbitals on the E5 and M2 fragments generate a continuum of bonding situations linked by the degree of localisation of the cluster LUMO.
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