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Telehealth refers to health care interactions that leverage telecommunication devices to provide medical care outside the traditional face-to-face, in-person medical encounter. Technology advances and research have expanded use of telehealth in health care delivery. Physical medicine and rehabilitation providers may use telehealth to deliver care to populations with neurologic and musculoskeletal conditions, commonly treated in both acute care and outpatient settings. Patients with impaired mobility and those living in locations with reduced access to care may particularly benefit. Video-teleconferencing has been shown to be effective for management of burn patients during acute rehabilitation, including reduced health care use expenses and less disruptions to care. Telehealth can facilitate developing inter-professional care plans. Patients with neurologic conditions including stroke, spinal cord injury, traumatic brain injury, and amyotrophic lateral sclerosis may use telehealth to monitor symptoms and response to treatment. Telehealth also may facilitate occupational and physical therapy programs as well as improve weight management and skin care in patients with chronic conditions. Other applications include imaging review in sports medicine, symptom management and counselling in concussion, traumatic brain injury, and pain management programs. Limitations of telehealth include barriers in establishing relationship between medical provider and patient, ability to perform limited physical examination, and differences in payment models and liability coverage. The expansion of telehealth services is expected to grow and has potential to improve patient satisfaction by delivering high quality and value of care.Niknamian S (2019) Systematic review on tele-wound-care in spinal cord injury (SCI) patients and the impact of telemedicine in decreasing the cost Volume 4: 2-6

Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behavior, such as pacing back and forth, somatic complaints, and rumination. Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings, and sense of well-being. Fear in human beings may occur in response to a specific stimulus occurring in the present, or in anticipation or expectation of a future threat perceived as a risk to body or life. In psychology, stress is a feeling of strain and pressure. Also this is one type of psychological pain. Cancer as mentioned by Drs. Zaminpira and Niknamian, is an Evolutionary Metabolic Disease (EMHC) which is caused by increasing the amounts of Reactive Oxygen Species (ROS) through the Butterfly Effect (BE) inside human eukaryotic cells. Therefore; increasing inflammation is a promising factor in the cause of cancer. The aim of this review and meta-analysis is to find the link between the depression, stress, fear and anxiety and the possibility of causing cancer. These emotional states have been observed in cancer patients as well. Anxiety and Fear are the two main emotional states which are the side effects of cancer disease, and also, high amounts of emotional stress and depression have been discussed in this review to raise the possibility in causing cancer.

Background: Coronaviruses are a group of related viruses that cause diseases in mammals and birds. In humans, coronaviruses cause respiratory tract infections that can range from mild to lethal. Mild illnesses include some cases of the common cold, while more lethal varieties can cause SARS, MERS, and COVID-19. The outbreak was identified in Wuhan, China, in December 2019, declared to be a Public Health Emergency of International Concern on 30 January 2020, and recognized as a pandemic on 11 March 2020.Introduction: Coronaviruses are the subfamily Orthocoronavirinae, within the family of Coronaviridae, order Nidovirales, and realm Riboviria. They are enveloped viruses with a positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry. The genome size of coronaviruses is approximately from 26 to 32 kilobases. Coronaviruses were first discovered in the 1930s and Human coronaviruses were discovered in the 1960s. The earliest ones studied were from human patients with the common cold, which were later named human coronavirus 229E and human coronavirus OC43. Other human coronaviruses have since been identified, including SARS-

Background: Approximately 80% of all viruses are RNA viruses and they contain their specific RNA helicases. Defective RNA helicases have been linked to infectious diseases (Viral Infections). Materials and Methods: The articles have gone through many types of research from the beginning of the epidemic of Coronaviruses through history and we introduced the neglected hypothesis of Shifting balance theory, Bateson-Dobzhansky-Muller model & Quantum evolution. In the ancestral population, the genotype is AABB. When two populations become isolated from each other, new mutations can arise. In one population A evolves into a, and in the other B evolves into b. When the two populations hybridize it is the first time A and B interact with each other. When these alleles are incompatible, we speak of Dobzhansky-Muller incompatibilities plus the role of MMA in mitochondria in spreading SARS-CoV-19 through populations and the result of an infection in COVID-19. Results:In viruses specifically COVID-19, Ribosomal Frameshift is programmed to allows the virus to encode multiple types of proteins from the same mRNA. HIV-1 (human immunodeficiency virus), RSV (Rous sarcoma virus), and all types of influenza viruses use Ribosomal Frameshift. they rely on frameshifting to create a proper ratio of normal translation and trans-frame (encoded by frameshifted sequence) proteins. Notably, its use in viruses is primarily for compacting more genetic information into a shorter amount of genetic material. Conclusion:to find the genome sequence of COVID-19 we also used Nanopore sequencing that introduced and manufactured by Oxford scientists, due to differences in the action of infection in the host, we could not reach any results since the Novel Virus has not a stable genome (which is quite dynamic) since through our deep research, each virus contains its specific genome sequencing and we cannot claim that COVID-19 has one specific genome sequence like MERS-CoV, SARS-CoV or any types of viruses which has been discovered and contains their specific genome.

This work is licensed under Creative Commons Attribution 4.0 License AJBSR.MS.ID.000696

Introduction: Cancer disease has become the first cause of death in the United States and world-wide. Most Researchers estimate that 595,690 of American people will die from cancer at the end of the year 2017. That means 1,600 deaths/day approximately. Cancer in modern societies is commonly treated with the combination of organ surgery, chemotherapy and radiotherapy which has many side effects and the high possibility of metastasis. Many kinds of diet strategies have been experimented. However, none of them have been particularly effective. Materials and Methods:According to Otto Warburg hypothesis in the 1930's, the cause of cancer is the change in the metabolism of mitochondrion in human cells. Low oxygen in tissues in combination with high blood glucose will change the cell respiration from aerobic to anaerobic which leads to fermentation type of respiration. Professor Thomas N Seyfried in 2012 proposed cancer as a metabolic-mitochondrial disease. He has mentioned that all cancer cells' mitochondria are damaged and do not work properly.Results: Mitochondrion is a microorganism living inside our cells and produce energy in the form of Adenosine Triphosphate (ATP) from fats, glucose and glutamine. In order to produce ATP, mitochondria need oxygen through the krebs cycle which is called "Aerobic Respiration". On the other hand, when the amounts of oxygen go under 30% in the tissues and cells, mitochondria cannot respire properly which causes the increase in the amounts of Reactive Oxygen Species (ROS) or better called "Inflammation" inside the cells and causes damage to the mitochondria. According to Professor Thomas N Seyfried, the main cause of cancer is the increase in ROS inside normal cells [Thomas N Seyfried et al., 2012]. Conclusion:In 2017 we (MAJ Dr. Sorush Niknamian and Professor Dr. Somayeh Zaminpira along with the continuous help of Professor Seyfried and Professor Stephanie Seneff hypothesized with the sponsorship of the Weston A. Price Foundation (WAPF), that cancer is an Evolutionary Metabolic Disease which we proposed in the 4 th International Conference in Medicine and Neurological Diseases which held in Fulda/Germany.

The turbojet engine operates on the ideal Brayton cycle (gas turbine) and consists of six main parts: diffusers, compressors, combustion chambers, turbines, afterburners and nozzles. Using computer code writing in MATLAB software environment, exergy analysis on all selected turbojet engine components, exergy analysis on J85-GE-21 turbojet engine for selective height of 1000-8000 meters above sea level at speeds of 200 m/s and temperatures of 10°C, 20°C and 40°C have been provided and then, according to the system functions, the system is optimized based on the PSO method. For the purpose of optimization, variables of Mach number, efficiency of the compressor, turbine, nozzle and compressor pressure ratio are considered in the range of 0.6 to 1.4, 0.8 to 0.95, 0.8 to 0.95 and 7 to 10, respectively. The highest exergy efficiency of different parts of the engine at sea level with an inlet air velocity of 200 m/s corresponds to a diffuser with 73.1%. Then, the nozzle and combustion chamber are respectively 68.6% and 51.5%. The lowest exergy efficiency is related to compressor with 4%. After that, the afterburner is ranked second with 11.6%. Also, the values of entropy produced and the efficiency of the second law before optimization were 1176.99 and 479 w/k respectively and the same values after optimization were 1129 and 51.4 w/k respectively which is identified. After the optimization process, the amount of entropy produced is reduced and the efficiency of the second law of thermodynamics has increased.