A tandem platinum dichloride-catalyzed cycloisomerization and rearrangement reaction of enynes leads to the formation of 2,4-pentadienals, 1-aryl-tetrahydro-1H-indenes, or 3-methylene-4-vinylcyclohex-1-enes; depending upon the substituent(s) and tether group of the enynes, the platinum dichloride-catalyzed cycloisomerization products, bicyclo-hept-2-enes, undergo a Claisen rearrangement, a 1,5-hydrogen shift, or a vinylcyclopropane rearrangement.
Let′s rearrange! Rh(PPh3)2(CO)Cl/AgBF4 has been found to be an efficient catalytic system in the rearrangement of azabicyclo[4.1.0]heptenes having an aryl and a cyclopropyl group in the 1‐ and 6‐position, respectively. This has led to the development of an efficient and simple method for the synthesis of arylhexahydroisoquinolines.
A new tandem PtCl2‐catalyzed cycloisomerization and rearrangement reaction of enynes leads to dienals, aryl‐tetrahydro‐1H‐indenes or methylenevinylcyclohexenes depending on the substituents.
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