Chemical variability of a plant from various continents or collected in different localities is well known and justifies its different biological activities. Thus, the present study was undertaken to evaluate the chemical variability of essential oils from leaves of Tridax procumbens Linn from five localities of Cote d'Ivoire. Essential oils have been extracted by hydrodistillation with yields varying from 0.077 to 0.079% depending on the locality. Gas chromatography and mass spectrometry analysis of essential oils showed a predominance of thymol (20.9 to 68.9%) in the oils from all the localities except that from Yamoussoukro which is of an α-acoradiene (28.9%) predominance. Several of the most important and variously distributed minor compounds consist of p-cymene (2.2 to 11.3%), β-caryophyllene (1.5 to 6.0%), β-selinene (1.8 to 10.0%), α-selinene (0 to 7.3%), elemol (0 to 16.0%), α-eudesmol (0 to 7.5%), 6,10,14-Trimethylpentadecan-2-one (0.9 to 7.2%) and phytol (0 to 7.2%). The comparative study of the chemical compositions of essential oils showed that thymol is a marker of the plant. Tridax procumbens acclimated in Côte d’Ivoire have been grouped into three chemotypes of thymol and other compounds.Keywords: Essential oils, Tridax procumbens, Chemical variability, Thymol, Chemical composition
KEYWORDS Terminalia superb Anticandidosic Ellagic acid derivative ABSTRACTThe aim of the present study was to optimize the anticandidosic activities of Terminalia superba (TEKAM4) and the identification of major compounds present in the most active chromatographic fraction. The hydroethanolic extract TEKAM4-X0 was prepared by homogenization employing a blender. Two derivatives extracts of TEKAM4-X0 (X1-1 and X1-2) were obtained by a liquid/liquid partition of TEKAM4-X0 in a mixture of hexane and water (v/v). Three chromatographic fractions (F1, F2 and F3) from X1-2 were separated by means of Sephadex-LH20 gel filtration chromatography. All the extracts were incorporated to Sabouraud according to the agar slanted double dilution method. Ketoconazole was used as standards for antifungal assay. The entire fractions were tested on the previously prepared medium culture containing 1000 cells of C. albicans. Antifungal activity was determined by evaluating antifungal parameters values (MFC and IC50). Lastly, the structures of 2 isolated compounds were elucidated by combination of Flash chromatography and spectroscopic methods, including MS, and multiple stage RMN experiments.
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