Patients treated with corticosteroids experienced significant improvement during the 3 months of intervention, with an effect size indicating a moderate clinical effect. Although a similar significant result following treatment with HA could not be shown, the effect size indicated a small clinical improvement. A higher number of patients in future HA studies would serve to clarify this point.

Background: Intratendinous Doppler activity has been interpreted as an equivalent of neovessels in the Achilles tendon and as a sign of tendinosis (AT). Aim: To evaluate the vascular response as indicated by color Doppler activity after repeated loading of both symptomatic and non‐symptomatic Achilles tendons. Material and methods: Ten non‐trained, healthy subjects ran 5 km. Ultrasound (US) Doppler activity was determined before and after the exercise. Eleven patients with chronic AT performed 3 × 15 heavy‐load eccentric exercise. The Achilles tendons were scanned before and immediately after the exercise. Results: Non‐symptomatic: six Achilles tendons in five subjects had intratendinous Doppler activity before the exercise. All but two subjects (80%) had intratendinous Doppler activity after running. Symptomatic: all patients had Doppler activity in the tendons, with a median color fraction before eccentric exercise of 0.05 (range 0.01–0.33). The Doppler activity did not disappear after exercise. Tendons with a color fraction below the median at baseline increased significantly after the exercise (P=0.02). Conclusion: The mere presence of Doppler in the Achilles tendon does not per se indicate disease. Eccentric exercise does not extinguish the flow during or after one training session in patients with chronic AT.

The paper explains the most important parameters for the use of colour and power Doppler in rheumatology. Recommendations for machine settings are given. The commonly encountered artefacts and their importance for image interpretation are explained.Most musculoskeletal ultrasound (US) is performed using grey-scale US, but newer US techniques include the use of Doppler US in the assessment of changes in tissue vascularisation that may occur in inflammatory conditions. 1-3 The Doppler evaluation provides useful clinical information regarding the presence or absence of flow. Guidelines have been suggested by the European League Against Rheumatism (EULAR) work group for the use of grey-scale US in musculoskeletal disease. 4 The guidelines address technical issues, training and standardisation of image acquisitions. However, no such guidelines exist for Doppler US. Standardisations of the methods for evaluating inflammation and the effect of the quality of the machine and image processing still need to be established.Correct interpretation of flow images requires knowledge of physical and technical factors that influence the Doppler signal. Artefacts caused by physical limitations of the modality or inappropriate equipment settings may result in displayed flow conditions that may differ considerably from the actual physiological situation. As a consequence, artefacts in Doppler imaging may be confusing and lead to misinterpretation of flow information.In this paper, we review colour Doppler and power Doppler (PD) US, as well as the artefacts and settings relevant for musculoskeletal US in rheumatology with focus only on soft tissue and joint inflammation. DOPPLER SIGNALThe Doppler effect is a change in wavelength (frequency) of sound resulting from motion of a source, receiver or reflector. As the US transducer is a stationary source and receiver, the Doppler effect arises from reflectors in motion-for all practical purposes these are the erythrocytes. When a pulse is reflected from erythrocytes, the frequency of the wave received differs from that, which is transmitted. This difference is known as the Doppler shift, named after the Austrian physicist and mathematician Chr. Andreas Doppler, who first described the phenomenon for light in 1843. 5There are two successive Doppler shifts involved. First, the sound from the stationary transmitting transducer is received by the moving erythrocytes. Second, the erythrocytes act as moving sources as they re-eradiate the US back toward the transducer, which is now the stationary receiver. These two Doppler shifts account for factor 2 in the Doppler equation:where: f D is the Doppler shift, f t is the transmitted frequency, f r is the received frequency, v is the blood velocity, h is the insonation angle (the angle between the US beam and the blood flow), and c is the speed of sound. The Doppler shift is thus directly proportional to the velocity of the flow, v, cosine to the insonation angle, h, and the transmitted frequency of the US, f t . 6 Pulsed DopplerThe Dopple...

Objective: To assess the interobserver reliability of the main periarticular and intra-articular ultrasonographic pathologies and to establish the principal disagreements on scanning technique and diagnostic criteria between a group of experts in musculoskeletal ultrasonography. Methods: The shoulder, wrist/hand, ankle/foot, or knee of 24 patients with rheumatic diseases were evaluated by 23 musculoskeletal ultrasound experts from different European countries randomly assigned to six groups. The participants did not reach consensus on scanning method or diagnostic criteria before the investigation. They were unaware of the patients' clinical and imaging data. The experts from each group undertook a blinded ultrasound examination of the four anatomical regions. The ultrasound investigation included the presence/absence of joint effusion/synovitis, bony cortex abnormalities, tenosynovitis, tendon lesions, bursitis, and power Doppler signal. Afterwards they compared the ultrasound findings and re-examined the patients together while discussing their results. Results: Overall agreements were 91% for joint effusion/synovitis and tendon lesions, 87% for cortical abnormalities, 84% for tenosynovitis, 83.5% for bursitis, and 83% for power Doppler signal; k values were good for the wrist/hand and knee (0.61 and 0.60) and fair for the shoulder and ankle/foot (0.50 and 0.54). The principal differences in scanning method and diagnostic criteria between experts were related to dynamic examination, definition of tendon lesions, and pathological v physiological fluid within joints, tendon sheaths, and bursae. Conclusions: Musculoskeletal ultrasound has a moderate to good interobserver reliability. Further consensus on standardisation of scanning technique and diagnostic criteria is necessary to improve musculoskeletal ultrasonography reproducibility.

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Conclusion. Estimates of synovial inflammatory activity by Doppler US and postcontrast MRI were comparable. Estimation of synovial inflammatory activity by the RI and color fraction parameters of US appears to be a promising method of detecting and monitoring inflammatory activity in patients with RA.

Ultrasound (US)-guided interstitial hyperthermia performed with the neodymium yttrium aluminum garnet laser with a diffuser tip involves placement of a laser fiber in solid tissue followed by irradiation from within the center of the tumor to be treated. The authors previously described the development of a US-guided technique that permits simultaneous interstitial laser irradiation and temperature measurements, with real-time US monitoring. With the use of a dedicated diffuser tip modification of the bare laser fiber, it has proved possible to produce spherical coagulations with a diameter comparable to that of liver metastases of clinical relevance. This technique was used in 11 patients with 16 colorectal liver metastases, 12 of which were radically ablated. Real-time US and interstitial temperature monitoring during treatment had a positive predictive value of 86% and negative predictive value of 100% in judging the final result. The technique is feasible, effective, and safe, but the effect on patient survival must be tested in future randomized clinical studies.

It was not possible to verify any association between intratendinous flow and pain at the start of the season or at the follow-up (end of the season). Intratendinous flow at the start of the season could not predict symptomatic outcome at the end of the season. The decrease in Doppler flow during the season might suggest that intratendinous flow could be part of a physiological adaptive response to loading and that intratendinous flow as previously believed is not always a sign of pathological changes.