Objectives: This study aimed to compare the color and fluorescence of five dentin ceramic systems with human dentin to enhance shade matching.Materials and methods: Five dentin ceramic systems, including Vita, GC, Creation, Noritake, and Ivoclar in 16 shades, and 12 human dentins, were prepared. The fluorescence and color coordinates were measured at 380-780 nm. A light source including a visible and a ultraviolet (UV) complemented with a geometry 45 illumination and 0 observer was used. The mean minimum difference in color coordinates and fluorescence efficiency was statistically analyzed before and after UV excitation by one-way ANOVA (p < 0.05). Post-hoc multiple comparisons were performed using the LSD test (p < 0.05).Results: While the fluorescence efficiency of Noritake and Ivoclar ceramics displayed no significant difference with natural dentin, Vita, GC, and Creation ceramics presented a lower fluorescence compared to the natural dentin (p < 0.05). Noritake and Ivoclar had a better color match with human dentin than the other ceramics. Studying the color differences under UV showed that just Creation offers statistically worse performance than the other ceramic. Conclusions:The color and fluorescence of the used different brands of dentin ceramic are not the same as the human dentin. However, Noritake and Ivoclar presented the most similarity.Clinical Significance: Knowledge of ceramic and natural teeth fluorescence is essential for acceptable reproduction of optical properties in esthetic restorations.