Uric acid (UA) is a metabolite of purine degradation and is involved in gout flairs and kidney stones formation. GLUT9 (SLC2A9) was previously shown to be a urate transporter in vitro. In vivo, humans carrying GLUT9 loss-of-function mutations have familial renal hypouricemia type 2, a condition characterized by hypouricemia, UA renal wasting associated with kidney stones, and an increased propensity to acute renal failure during strenuous exercise. Mice carrying a deletion of GLUT9 in the whole body are hyperuricemic and display a severe nephropathy due to intratubular uric acid precipitation. However, the precise role of GLUT9 in the kidney remains poorly characterized. We developed a mouse model in which GLUT9 was deleted specifically along the whole nephron in a tetracycline-inducible manner (subsequently called kidney-inducible KO or kiKO). The urate/creatinine ratio was increased as early as 4 days after induction of the KO and no GLUT9 protein was visible on kidney extracts. kiKO mice are morphologically identical to their wild-type littermates and had no spontaneous kidney stones. Twenty-four-hour urine collection revealed a major increase of urate urinary excretion rate and of the fractional excretion of urate, with no difference in urate concentration in the plasma. Polyuria was observed, but kiKO mice were still able to concentrate urine after water restriction. KiKO mice displayed lower blood pressure accompanied by an increased heart rate. Overall, these results indicate that GLUT9 is a crucial player in renal handling of urate in vivo and a putative target for uricosuric drugs.Electronic supplementary materialThe online version of this article (10.1007/s00424-018-2190-4) contains supplementary material, which is available to authorized users.
Anal intercourse (AI) among heterosexuals is an understudied and taboo subject. This 2017 Swiss national study aims to describe the characteristics and motivations of heterosexual young adults practicing AI. Participants with any same-sex experience, same-sex attraction or non-heterosexual identity were excluded. The Federal Statistical Office provided the initial sample and potential participants were recruited through postal mail inviting them to an online survey (response rate 15.1%). According to our research question, the sample used in this paper constituted of 3892 participants (52% males; 54% of the overall sample, mean age 26.3 years). Overall, 55% of women and 56% of men had never experienced AI, respectively 17% and 12% had done it once and 28% and 32% more than once. We found that participants engaging in AI had higher odds of practicing intercourse while intoxicated, being younger at first sexual experience, not using condom at last intercourse and reporting a history of sexual transmitted infections. The main reason reported by both genders for engaging in their first AI was being curious followed by being in love. In conclusion, AI is a widespread practice among heterosexual young adults and health professionals should be especially attentive to it.
Background Studies on virgins remain scarce. This study explores the characteristics of virgin young adults, the reasons for remaining virgin, and its potential social and health implications. Methods: Data were drawn from the 2017 Swiss study on sexual health and behaviour among young adults. A total of 5175 participants (mean age 26 years ± 0.01) were divided into virgins and non-virgins. Virginity was defined as never having had a sexual partner, defined as a person with whom the participant has had sexual contact with or without penetration. Results: A total of 275 (5.3% (95% CI: 4.7–6.0), 58% males) were virgins. Virgins had higher odds of being male (aOR: 2.27 (95% CI: 1.62–3.17)) and reporting poorer health (1.43 (1.07–1.92)). They had lower odds of living on their own (0.24 (0.18–0.32)), being satisfied with their social life (0.78 (0.72–0.85)), having experimented with substances (e.g. drunkenness, 0.27 (0.19–0.67)) and having used online dating (0.52 (0.26–1.12)) or pornography (0.67 (0.42–0.94)). The main reason for remaining virgin was ‘I have not found the right person’ for females, and ‘I have not had the occasion’ for males. Conclusions: Among young adults, 1 in 20 is a virgin. Virgins do not seem to have gone through the usual experimentations of adolescence, are less socially driven and reported more health challenges. The main reason for remaining a virgin reveals gender-stereotyped responses. Sexual inactivity among young adults should be considered by health professionals to ensure the absence of distress and open discussion for potential questions.
Background There is a gap in the literature regarding data on sexting among youth under the age of 16 whereas the problems related to this practice could affect them more because of their ongoing development. This study aims to determine the prevalence rate and characteristics of sending one's own sexually related image among middle‐school teens. Methods Data were obtained from a web‐based in‐school survey conducted between October 2019 and February 2020. The sample comprised 3006 (mean age 13.7; 50.2% males) 10th‐grade pupils in the canton of Vaud (Switzerland). Participants were asked “Have you ever sent a sexually related/sexy image of yourself?”. Analysis of variance/chi‐square tests and multinomial regression analyses were used to compare the groups. Results Overall, 93.0% reported never, 3.7% once and 3.3% several times. No gender differences were found. Sending was associated with older age, low academic performance, cyberbullying victimization and reception of unsolicited sexually related images. Conclusions Education and health professionals should be aware that it is necessary to discuss the theme, perhaps with a more global approach including pressure, consent, exchange of nonsexual images, and so on from an early age. The context and reasons for sending remain to be explored, particularly to determine if the pressure is greater at this age.
OBJECTIVE: To compare the characteristics of and use of the healthcare system by healthy youths depending on whether they had discussed transition to adult health care with their paediatrician or not. METHODS: Data were drawn from the fourth wave of the GenerationFRee study (2018–2019) conducted in the 11 post-mandatory schools of the canton of Fribourg, Switzerland. The sample included 931 young people (mean age 19.4 years). Participants were categorised into three groups: those who had discussed transition with their p ediatrician (n = 176; 19%), those who had not (n = 286; 31%) and those who did not know (n = 469; 50%). Analyses were stratified by gender through bivariate analysis and post-hoc tests with a Bonferroni-type adjustment. RESULTS: The majority of participants did not know whether or not they had discussed transition. Across all groups, it was found that youths met their primary care physician at a higher rate through family. Meeting with the primary care physician through the paediatrician occurred at a higher rate when youths had discussed transition. Girls with a below average socioeconomic status and boys with advanced puberty onset were more likely to have discussed transition. CONCLUSION: Our results show that youths are not well informed about the transition process. However, youths who have discussed transition appear to be more involved with the healthcare system as they are more likely to have a primary care provider. In order to avoid discontinuity of care, professionals should approach transition to adult care systematically with all their patients.
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