A series of 4-aminobutanetriols and 5-aminopentanetetrols was synthesised and their co-ordination abilities towards copper(ii) studied by potentiometry and spectroscopic techniques (UV/VlS, ESR and CD). The basic binding mode involves the amino nitrogen and the adjacent deprotonated hydroxyl group. The latter donor acts as a bridge between two metal ions giving stable dimeric species. No monomeric complexes were detected in the systems studied. The formation of the alkoxo-bridged complexes seems to be the most characteristic feature of the investigated ligands. Other hydroxyl donors are also involved in the metal-ion binding. The stability constants calculated from the pHmetric data showed that the chirality of the carbons in an aminoalcohol molecule may have a considerable effect on its co-ordination ability.
A series of diaminoalcohols (1.5-diaminotriols and 1,6-diaminotetroIs) have been synthesised and their co-ordination abilities towards Cu" studied by potentiometry and spectroscopic techniques (UV/VlS, EPR and CD). Both amino groups act as anchoring sites for two metal ions. Thus, two independent NH,, 0chelates are formed leading to dimeric complexes in which two metal ions are bound to two N-terminal atoms of the 1,5-or 1.6-diaminoalcohols. In all cases studied both ligand conformation and absolute configuration have a distinct impact on the stabilities of the complexes formed.There is much of chemical and biochemical interest in metal complexes with a variety of amino polyalcohols. Aminoalcohols offer many possibilities for metal ion co-ordination, providing various N,O environments.The structures of the complexes formed are monomeric and very often oligomeric with unusual physicochemical properties. Biologically, amino sugars, naturally occurring aminoalcohol analogues, may act as powerful ligands for metal ions like Cu" with the amino group usually providing an efficient anchor for the metal ion. 1,5*9-12Recent work on the linear monoaminoalcohols (4-aminobutanetriols and 5-aminopentanetetrols) ' ' has shown that
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