Abstract:The structures and stereochemistry of 14 taxanes isolated from Taxus cunadensis have been rigorously established by high-resolution NMR techniques and mass spectrometry. Taus canadensis is the only yew that accumulates 9-dihydro-13-acetylbaccatin 111 (also called 7,9-deacetylbaccatin VI) as the most abundant taxane. Five 9-dihydrotaxanes derived from the Canadian yew are novel natural products not reported in the needles of other species of yew (8-11, 14, Fig. 1).

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