Introduction Marjolin's Ulcer (MU) means all cutaneous malignancies developed on old unsteady scars. The general objective of this study was to report the MU cases in Congo with a literature review. It was a retrospective study conducted at University Teaching Hospital in Brazzaville from January 1998 to December 2017 (a 20-year period). The in-patients for cutaneous cancer histologically confirmed, arose on scarring skin lesions progressive were included. The epidemiological, clinical, histopathological and therapeutical variables were collected. Seven patients were identified. They represented 1.9% of skin cancers. The middle age was 44.4 years. The female predomination was noted with a sex ratio of 2.5. The burn scars was the etiological factor found to all our patients (100%). None of patients had an appropriate care of initial wound. The average time limit of the onset of MU was 34 years. The anatomopathologic examination revealed a squamous cell carcinoma to all our patients (100%). Carcinologic exeresis carried out to one (01) patient (14.28%). The amputation: three (03) patients (42.85%) and the disarticulation: two (02) patients (28.57%). The chemotherapy six (06) patients (85.71%). The decease arose five (05) patients (71.42%) and the entire remission reached to a woman patient (14.28%). This study confirmed the rareness and the severity MU; it also reveals the diagnosis lateness of a great death-rate. The care of quality of burns and chronic injuries, the awareness of patients together with the care givers training could help to improve the prognosis of this affection.
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