Non-Hunner-type IC is characterized by severe fibrosis and increased mast cell infiltration, whereas Hunner-type IC is characterized by severe inflammation and urothelial denudation in the entire bladder. Fibrosis in the bladder of IC/BPS patients was correlated with increased urinary frequency and decreased bladder capacity.

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Abstract-Provable lower bounds are presented for the information rate I(X; X + S + N ) where X is the symbol drawn independently and uniformly from a finite-size alphabet, S is a discrete-valued random variable (RV) and N is a Gaussian RV. It is well known that with S representing the precursor intersymbol interference (ISI) at the decision feedback equalizer (DFE) output, I(X; X + S + N ) serves as a tight lower bound for the symmetric information rate (SIR) as well as capacity of the ISI channel corrupted by Gaussian noise. When evaluated on a number of well-known finite-ISI channels, these new bounds provide a very similar level of tightness against the SIR to the conjectured lower bound by Shamai and Laroia at all signalto-noise ratio (SNR) ranges, while being actually tighter when viewed closed up at high SNRs. The new lower bounds are obtained in two steps: First, a "mismatched" mutual information function is introduced which can be proved as a lower bound to I(X; X + S + N ). Secondly, this function is further bounded from below by an expression that can be computed easily via a few single-dimensional integrations with a small computational load.Index Terms-Channel capacity, decision feedback equalizer, information rate, intersymbol interference, lower bounds, mutual information.