OBJECTIVE -We reported strong relations between serum concentrations of persistent organic pollutants (POPs), especially organochlorine (OC) pesticides or nondioxin-like polychlorinated biphenyls (PCBs), and prevalence of diabetes in a U.S population with background exposure to POPs. Here, we investigated POPs and insulin resistance, a frequent pathogenic precursor of type 2 diabetes.RESEARCH DESIGN AND METHODS -Serum POPs and homeostasis model assessment of insulin resistance (HOMA-IR) were investigated cross-sectionally in 749 nondiabetic participants aged Ն20 years. Nineteen POPs in five subclasses were selected, detectable in Ն60% of participants.RESULTS -Among subclasses, OC pesticides were most strongly associated with HOMA-IR. Adjusted geometric means of HOMA were 3.27, 3.36, 3.48, and 3.85 (P for trend Ͻ0.01) across quartiles of OC pesticides. The relationship strengthened with increasing HOMA-IR percentile: adjusted odds ratios comparing the highest versus lowest POPs quartile were 1.8 for being Ն50th percentile of HOMA-IR, 4.4 for being Ն75th percentile, and 7.5 for being Ն90th percentile. Associations with elevated HOMA-IR appeared to be specific to oxychlordane and trans-nonachlor but also were found for two nondioxin-like PCBs. No HOMA-IR associations were seen in the other three POP subclasses. The association between OC pesticides and HOMA-IR tended to strengthen as waist circumference increased, with no apparent association in the lowest quartile of OC pesticide concentrations.CONCLUSIONS -These findings, coupled with those concerning diabetes prevalence, suggest that OC pesticides and nondioxin-like PCBs may be associated with type 2 diabetes risk by increasing insulin resistance, and POPs may interact with obesity to increase the risk of type 2 diabetes.
Diabetes Care 30:622-628, 2007
Autism spectrum disorder (ASD) is a neurodevelopmental disorder believed to be associated with heavy metal exposure, especially mercury (Hg), and is characterized by disturbances in metal elimination. Various studies correlated elevated heavy metal body burden with ASD diagnoses as evidenced by increased urinary porphyrin levels in patients. Urinary porphyrins were also determined in Korean patients diagnosed with ASD (n = 65) who visited AK Eastern Medicinal Clinic in Kangnam-gu, Seoul, from June 2007 to September 2008, compared to controls (n = 9) residing in the same area, by means of Metametrix (CLIA-approved) laboratory testing. Further, urinary organic acids as indicators of hepatic detoxification/oxidative stress were also analyzed among patients diagnosed with ASD. Significant increases were found in patients diagnosed with ASD for proporphyrins, pentacarboxyporphyrin, precoproporphyrin, coproporphyrins, and total porphyrins. Significant correlations were observed between hepatic detoxification/oxidative stress markers and urinary porphyrins. In agreement with published data, the present results demonstrated that measurement of porphyrins serves as a reliable tool for diagnosis of heavy metal involvement in ASD.
Objectives: We investigated relation between HDL-cholesterol and the incidence of impaired fasting glucose in obese and normal body weight by gender in Korean adults. Methods: 6,438 subjects aged 40-59 years (2,197 impaired fasting glucose, 4,241 normoglycemia) were selected except the patients with cardiovascular disease and pregnant women using 2016 KNHANES data. We analyzed the relation of impaired fasting glucose and HDLcholesterol by BMI. Results: In both men and women regardless of BMI, who with low HDL-cholesterol significantly higher risk of impaired fasting glucose than who with normal HDL-cholesterol in unadjusted model. In except men with obesity, who with low HDL-cholesterol significantly higher risk of impaired fasting glucose than who with normal HDL-cholesterol when age, smoke, drink, exercise adjusted. In addition, women with normal BMI (OR, 1.82; 95% CI, 1.42-2.33) higher risk of impaired fasting glucose than women with obesity (OR, 1.57; 95% CI, 1.14-2.17). Conclusions: It is necessary to management of HDL-cholesterol to control impaired fasting glucose, except for obese men.
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