Synthesis of 3-methoxy acetophenone with substituted benzaldehydes resulted in a number of novel chalcones. The chalcones were then treated to a cyclization reaction with hydroxylamine hydrochloride in ethanol to enable the synthesis of 3-methoxy acetophenone isoxazole derivatives. After purification, the structures of the synthesized compounds were identified using TLC, FTIR, 1H NMR, 13C NMR and a Mass spectroscopy. The carrageenan-induced paw edema method was used to test the compounds for anti-inflammatory activity. Based on the findings, the three compounds appeared to be moderate to extremely active.
As they represent a sizable class of naturally occurring and synthetic chemicals with potent biological activity in the pharmaceutical and biological fields, 1, 3 Thiazine heterocycles are of great interest. The goal of this project was to create the Schiff base. 3,-Methoxychalcone derivative of 1,3-thiazine. TLC, IR, 1HNMR, 13C NMR, each mass calculation were accustomed to identify the compositions of recently created targeted substances. Using an Elevated plus maze, the test compounds (B1–11) were examined for their ability to reduce anxiety. The most effective CNS medications were B1 and B8 compounds.
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