Filariasis is a major public health problem in south East Asia including India. It is transmitted by bite of culex mosquito and most commonly caused by Wauchereria bancrofti. Conventional mode of diagnosis is demonstration of microfilaria in peripheral blood smear and body fluid. Coexistence of microfilaria with neoplastic lesions are rare. We present herewith 5 interesting cases of neoplastic lesions where microfilaria were coexistent with one case each of non Hodgkin lymphoma, metastatic adenocarcinoma of supraclavicular lymph node, metastatic adenocarcinoma of cervical lymph node, Infiltrating ductal carcinoma of breast, benign phylloides tumor of breast.
Journal of Surgery IntroductionCancer of the breast in women is a major health burden worldwide. In the developed countries of the West, breast cancer is the single largest cause of death in women between the ages of 35 and 54, with a mortality rate of 28.4 per 100000 females per year in UK [1] and 20.7 per 100,000 (age-standardized mortality rates) women in US [2]. It accounts for 25% of all malignant disease in woman and approximately one in twelve women in America and UK will suffer from some kind of breast diseases during their lifetime [3]. In India, cancer of the breast has been replacing cancer of cervix as the leading site of cancer in most urban population based cancer registries [4]. Since the early detection of breast cancer improves the prognosis in most cases, regular screening of an increasingly large proportion of the female population has been widely advocated [5,6].Mammography and ultrasound imaging are established as the main non-invasive diagnostic procedure used in the identification of breast cancer in screening population and for further evaluation in already identified cases. Unfortunately, these techniques provide rather limited sensitivity and specificity. Over the past few year contrast material-enhanced breast magnetic resonance [7][8][9][10] (MR) imaging has evolved and has become an important tool in the evaluation of breast abnormalities, with a reported sensitivity as high as 94% -100% and AbstractBackground: Early diagnosis is an important factor for successful outcome in breast cancer. Current existing prognostic and predictive tool like ER, PR and HER2 status have main utility to guide whether a patient should or should not receive adjuvant endocrine or targeted therapy and situation has become more complex after the discovery of genomic tests like oncotype Dx etc. So the need to enhance the understanding of the disease process and treatment response, a hunt for suitable tumor marker is still on.Sample collection: 5-7 ml fasting peripheral venous blood was withdrawn from newly diagnosed breast cancer patients. The subjects were properly matched in terms of age, sex, dietary habits and other parameters. The blood was centrifuged and resultant supernatant serum was put into the 3 ml ependorf tube and the specimen was immediately snap frozen in liquid nitrogen and was transferred to the HRMAS lab where it was stored at -80ºC. HRMAS experiment:The collected samples (Malignant 32, Benign 32 and Healthy Control 28) were thawed and subjected to 800 MHz HRMAS spectrometer. The serum samples were recorded in native form using TSP as an internal standard and a coaxial insert. The spectra were acquired using 1D single pulse and Carr-Purcell-Meiboom-Gill (CPMG) pulse sequence with water suppress [PRESET-90 degree-(δ-180°-δ)n-Aq] with a echo time of 40 ms. The HRMAS findings were correlated with the standard histopathological report. Results:The 3D scattered PCA score plot of serum (explaining 83% of the total variance showed distinct group separation among the healthy, fibroadenoma and mal...
The role of fine needle aspiration cytology in diagnosing recurrent and metastatic sarcomas has been well dealt with, however; its utility in rendering a primary diagnosis of sarcoma still remains a topic of debate. The present study evaluates the scope of FNAC along with adjunctive techniques including cell blocking and immunocytochemistry in diagnosing and subtyping of soft tissue tumors. A total of 71 patients presented with musculoskeletal lesions underwent fine needle aspiration. Cell blocks were contributory in exact subtyping in 41/56 (73.2%) cases. Round cell tumors were the most easily subtyped tumors with 19/20(95%) subtyped accurately. Similarly, 8/17(47.1%) of pleomorphic tumors, 9/19(47.3%) of spindle cell tumors, 1/1(100%) of myxoid tumors, 0/1(0%) epithelioid tumors, 0/2(0%) of lipomatous tumors, 1/2(50%) of mixed tumors and 3/9(33.3%) of other tumors could be accurately subtyped using ancillary techniques. Histopathological correlation was available in 51 cases.
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