A sequential transformation based on a titanium-mediated aldol reaction from chiral α-tert-butyldimethylsilyloxy ketones followed by reduction of the resultant aldolates with LiBH 4 provides a straightforward access to syn-1,3-diols. These diols, containing up to three new stereocentres, can
Highly Stereoselective Synthesis of syn-1,3-Diols Through a Sequential Titanium--Mediated Aldol Reaction and LiBH4 Reduction. -(ESTEVE, J.; MATAS, S.; PELLICENA, M.; VELASCO, J.; ROMEA, P.; URPI*, F.; FONT-BARDIA, M.; Eur.
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