We have prepared Chinese traditional herb Bletilla striata into microspheres as a novel embolic agent for decades. The aim of this study was to evaluate the biocompatibility of Bletilla striata microspheres (BSMs). After a thermal test of BSMs in vitro, the cell biocompatibility of BSMs was investigated in mouse fibroblasts and human umbilical vein endothelial cells using the methyl tetrazolium (MTT) assay. In addition, blood biocompatibility was evaluated. In vivo intramuscular implantation and renal artery embolization in rabbits with BSMs were used to examine the inflammatory response. The experimental rabbits did not develop any fever symptoms after injection of BSMs, and BSMs exhibited no cytotoxicity in cultured mouse fibroblasts and human umbilical vein endothelial cells. Additionally, BSMs exhibited high compatibility with red blood cells and no hemolysis activity. Intramuscular implantation with BSMs resulted in a gradually lessened mild inflammatory reaction that disappeared after eight weeks. The occlusion of small renal vessels was associated with a mild perivascular inflammatory reaction without significant renal and liver function damage. In conclusion, we believe that BSMs exhibit high biocompatibility and are a promising embolic agent.
A composite tubular truss bridge has been widely used in highway projects since its short construction period and excellent mechanics characteristic. The joint's configuration and deformation of the composite truss bridge are of vital importance. Concrete filled tubular joint (CFTJ) has been approved as an effective way to enhance the loading capacity. While the bonding force between concrete and rectangular tube is not distributed uniformly, which will cause the bond-slip behavior in the tube. To improve the interface bonding strength, perfobond rib is installed inside tube on the joint. The paper represents the damage mechanism both CFTJ and CFTJ with perfobond rib through experiment calibration and numerical methods. The author proposes a new method to evaluate the steel joint's damage and fracture based on the stress-modified fracture strain model. The damage model which considers both critical fracture strain and stress triaxiality is calibrated by experiment to validate its accuracy. The user subroutine tool provided by commercial software ABAQUS is implemented to establish the damage model. Through analysis of CFTJ and CFTJ with perfobond rib, CFTJ with perfobond rib is found to have considerably much high constraint capability to concrete than CFTJ. The damage mechanism difference of the two types of joints is also compared in the paper.
The cable saddle on top of pylon not only helps the main cable pass through the summit of design form, but also transmits the enormous force to the pylon. An imbedded cast iron cable saddle is going to be adopted for a single pylon and two span cable stayed bridge. A cast in situ concrete foundation, which is called a concrete mount in this context, bears the imbedded cable saddle underneath. Due to the cambered shape of the bottom face of this imbedded cable saddle, the local compressive stress distribution on the contact part with the concrete mount may not be uniform. The finite element method is used to investigate the feature of the local compressive behaviour for the concrete mount. According to the results, the reduction factor for nonuniform local compression is approximately 0.73. This cable saddle structure could meet the local compression bearing capacity via theoretical verification, and indirect reinforcement under local compressive pressure is recommended to keep the structure in good condition for the serviceability limit state.
<p>The cable saddle on top of pylon not only helps the main cable pass through the summit of design form, but also transmits the tremendous force to the pylons. An imbedded cast iron cable saddle is proposed for a single pylon and two spans cable stayed bridge. Due to the arched shape of the cable saddle, the local compressive pressure on concrete bed may not be uniform. A plain strain FE model and A solid FE model is adopted to investigate the stress distribution in concrete foundation. The reduce factor for nonuniform local compression is about 0.73. This cable saddle structure can meet the local bearing capacity via theoretical verification, which could provide an example for the similar type of structures.</p>
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.